Use of O-Acyl Isopeptides to Identify New Functions of Amyloid β Peptides

スポンサーリンク

概要

• 論文の詳細を見る
• 2011-03-01

著者

• Kiso Y

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• Kinoshita Yuko

  Department Of Oriental Medicine Nihon University School Of Medicine

• Wang Hui

  Department Of Clinical Laboratories Peking Union Medical College Hospital Chinese Academy Of Medical

• Sohma Youhei

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kiso Yoshiaki

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Taniguchi Atsuhiko

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science 21st Century Coe

• Kiso Yoshiaki

  21st Century Coe Program Kyoto Pharmaceutical University

• Yamasaki Moe

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science And 21st Century

• Kiso Yoshiaki

  Kyoto Pharmaceutical Univ. Kyoto Jpn

• Mukai Hidehito

  Graduate School Of Materials Science Nara Institute Of Science And Technology

• Kiso Yoshiaki

  Protein Research Group Riken Genomic Sciences Center

• HIRAYAMA Yuta

  Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace

• MUKAI Hidehito

  Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmace

• Yamasaki Moe

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

• Hirayama Yuta

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

• Wang Hui

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

• Mukai Hidehito

  Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

• KISO Yoshiaki

  Department of Ecological Engineering, Toyohashi University of Technology, JAPAN.

• Wang Hui

  Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University

関連論文

• Development of New Photoresponsive Paclitaxel Prodrug
• Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
• "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
• "Click Peptide" Based on the "O-Acyl Isopeptide Method" : Development of Chemical Biology-Oriented Alzheimer's Disease-Related Aβ1-42 Analogues
• Controlled Drug Release : Design and Application of New Water-soluble Prodrugs
• Spontaneously Regenerable Prodrug : Design and Synthesis of Water-soluble Prodrugs of HIV Protease Inhibitors
• New Type Prodrugs of Anti-HIV Agents Consisting of the HIV Protease Inhibitor and Reverse Transcriptase Inhibitor
• Synthesis and Activity of a New Type of Anti-HIV Agents, Conjugate of HIV Protease Inhibitor with Reverse Transcriptase Inhibitor
• Synthesis of an HIV-1 Protease Analogue by the Chemoselective Ligation Method Using a New Disulfide Type Linker
• Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
• The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
• Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
• P-262 "O-ACYL ISOPEPTIDE METHOD" FOR THE EFFICIENT SYNTHESIS OF DIFFICULT SEQUENSE-CONTAINING PEPTIDES : UTILIZATION OF "O-ACYL ISODIPEPTIDE UNIT"
• RSPICE: A Fast and Robust Timing Simulator for Digital MOS VLSI (Special Section on VLSI Design and CAD Algorithms)
• Development of Spontaneously Regenerable Water-Soluble Prodrugs Based on the Peptide Chemistry : Importance of Drug Release Time for the Improvement of Gastrointestinal Absorption
• Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere
• Small-sized HIV Protease Inhibitors Containing Allophenylnorstatine as a Substrate Transition-state Mimic
• Design of HIV Protease Inhibitors Based on the Transition State Analogue Concept
• Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
• Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
• Synthesis of HIV Protease Dipeptide Inhibitors and Prodrugs
• Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
• Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
• Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
• Design and Synthesis of Conformationally Constrained Dimerization Inhibitors of HIV-1 Protease
• Acupuncture stimulation to the sacral segment affects state of vigilance in rats
• Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
• Structural Analysis of Amyloid-β Protein Fibrils Formed in Raft-Like Model Membranes
• Inhibition of Amyloid β-Protein Aβ-(1-42) Induced Cytotoxicity by Helical Aβ Analog
• Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
• Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
• P-296 DEVELOPMENT OF RESIN SUPPORTED EVANS-TYPE CHIRAL AUXILIARY FOR SOLID-PHASE ASYMMETRIC REACTION
• Modification of P4 Position in β-secretase (BACE1) Inhibitors Containing Phenylnorstatine
• Design of β-Secretase (BACE1) Inhibitors with Carboxylic Acid Bioisosteres
• O-N Intramolecular Acyloxy Migration Reaction : from the Prodrug Strategy to the Migration of Protective Groups in Amino Acids
• "Click Peptide" Based on the "O-Acyl Isopeptide Method" : an Efficient Preparation of Amyloid β Peptide 1-42 Mutants
• In vitro activity of meropenem and four other antibiotics against 554 clinical strains obtained from Beijing in 1999
• In-vitro antibacterial activities of cefpiramide and other broad-spectrum antibiotics against 440 clinical isolates in China
• Role of oxidative stress in elevated blood pressure induced by high free fatty acids
• SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
• High-throughput Screening Method for Ligand Peptides Using Capillary Electrophoresis-Mass Spectrometry (CE-MS)
• A Novel S-Acyl Isopeptide Method for the Synthesis of Difficult Sequence-Containing Peptide
• Isopeptide Method : A Racemization-Free Peptide Synthesis by Segment Condensation
• Design and Synthesis of Inhibitory Peptides against EGF Receptor Dimerization
• SAR study of BACE1 inhibitors containing pyridine derivatives
• Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
• Chemical Synthesis of 71-meric Neuregulin 1-β1
• Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
• "O-Acyl Isopeptide Method" for the Synthesis of Difficult Sequence-Containing Peptides : Application to the Synthesis of Amyloid β Peptide (Aβ) 1-42
• Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents
• Effect of the Phenyl Ring Modification on the Antitumor Activity of Anti-Microtubule Agent Dehydrophenylahistin
• Uptake Mechanisms of FITC-Oligoarginine Conjugates in HeLa Cells
• Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
• Small Peptide-based Medicinal Chemistry for Intractable Disease
• A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis
• New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
• P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
• Development of a New Synthetic Method for Monodehydro-2,5-diketopiperazines
• Synthetic Study of Anti-microtubule Diketopiperazines : Phenylahistin and Aurantiamine
• Studies on N^〈in〉-Protecting Groups during the Synthesis of Trp : Containing Cystine Peptide by Silyl Chloride Sulfoxide Method
• A Reductive Acidolysis Final Deprotection Strategy in Solid Phase Peptide Synthesis Based on Safety-Catch Protection
• Effect of Dipeptidomimetics on Malaria Parasite Proliferation Inhibition Targeting Plasmepsin
• Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
• Synthesis of Human C-Type Natriuretic Peptide 22 Using Chlorotrityl Resin and Tetrafluoroboric Acid Deprotection
• O-N Intramolecular Acyl and Acyloxy Migration Reaction in the Development of Water-Soluble Prodrugs of Taxoids
• A Novel Method for the Synthesis of Difficult Sequence-Containing Peptides via O-Acyl Isopeptides : The Use of O-N Intramolecular Acyl Migration Reaction
• Development of New Water-Soluble Prodrugs Based on Intramolecular Nucleophilic Reactions in Peptide Chemistry
• Non-genomic Effects of Steroids in Neuroendocrine Systems
• SYNTHESES AND STRUCTURE-ACTIVITY RELATIONSHIPS OF SMALL-SIZED ATRIAL NATRIURETIC PEPTIDE (ANP) DERIVATIVES
• Solid Phase Synthesis of a Mercaptoamide Peptide Using New Linkers
• Antibacterial effects of three experimental quaternary ammonium salt (QAS) monomers on bacteria associated with oral infections
• Development of "O-Acyl Isopeptide Method"
• Click Peptide : Application to E22Δ-type Mutant of Amyloid β Peptide
• Click Peptide : In Situ Production of pyroGlu-Abeta from the O-Acyl Isopeptide
• Use of O-Acyl Isopeptides to Identify New Functions of Amyloid β Peptides
• Lightweight Precision-Adaptive Time Synchronization in Wireless Sensor Networks
• Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
• Screening Methodology for Discovery of Inhibitory Peptides against Pathogenic Proteins using a Plug-plug Affinity Capillary Electrophoresis Technique
• Optimization of Peptidomimetic Plasmepsin Inhibitor Containing Allophenylnorstatine Using Basic Substituent for Malaria Treatment
• Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
• Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
• Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
• Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
• Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure
• Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy
• Isotope Labeling-assisted Quantitative Evaluation of Refolding Conditions of a Recombinant Disulfide Protein
• Intact Cell-based SPR Analyses of Interactions between EGF and its Receptor
• Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent
• Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues
• On the existence of nonnegative radial solutions for elliptic system
• 3A17 Biliary Reconstoructive Procedures for Treating Congenital Biliary Dilatation in Children in China
• Morphological analysis of astrocytes in the hippocampus in mechanical asphyxiation
• Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease
• Quantitative Analyses of Disulfide Bond Formation in Proteins Using ^O-Labeled Peptide Standards
• Novel Neutrophil-Activating Cryptides Hidden in Mitochondrial Cytochrome c : Identification and Structure-Activity Studies
• Design and SAR Study of Tripeptidic BACE1 Inhibitors
• Synthesis of O-Acyl Isopeptide by Use of Native Chemical Ligation to Efficiently Construct Hydrophobic Polypeptide
• Homoplantaginin Modulates Insulin Sensitivity in Endothelial Cells by Inhibiting Inflammation
• Influence of different adherend materials and combinations on in vitro shear bond strength
• SUPPRESSIVE EFFECT OF ACUPUNCTURE STIMULATION TO THE SACRAL SEGMENT ON THE STATE OF VIGILANCE AND THE BRAINSTEM CHOLINERGIC NEURONS

もっと見る 閉じる

スポンサーリンク