Hayashi Yoshio | Department Of Medicinal Chemistry Center For Frontier Research In Medicinal Science Kyoto Pharmaceut

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著作論文

Development of New Photoresponsive Paclitaxel Prodrug
Phototaxel : Development of First Photoresponsive Prodrug of Paclitaxel via Modification of Phenylisoserine Moiety
"Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues
Racemization-Free Segment Condensation Based on Isopeptide Method : An Efficient Preparation of Peptides on Solid Support
The Synthesis of Bioactive Peptides Based on O-Acyl Isopeptide Method : Application of O-Acyl Isodipeptide Units
Development of Racemization-Free "O-Acyl Isopeptide Method" Utilizing the "O-Acyl Isodipeptide Unit"
Novel BACE1 Inhibitors : Design Approach Focused on Inhibitor's Conformer
Structure-Activity Relationship Study of BACE1 Inhibitors Containing Chelidonamide
Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation
Synthesis and Activity of Tetrapeptidic Human T-cell Leukemia Virus Type I Protease Inhibitors Possessing Different P_1'- and P_3-cap Moieties
Design of BACE1 Inhibitors : Replacing the P_1' Residue with Non-Acidic Moiety
Synthesis of Negamycin and Its Derivatives as Potential Therapeutic Agents for Duchenne Muscular Dystrophy
Structural Analysis of Amyloid-β Protein Fibrils Formed in Raft-Like Model Membranes
Inhibition of Amyloid β-Protein Aβ-(1-42) Induced Cytotoxicity by Helical Aβ Analog
Phenylthionorstatine as a Transition-State Mimic in BACE1 Inhibitors
Tripeptide Mimetics with Potent Inhibitory Activity against Malarial Aspartic Protease Plasmepsin II
SAR study of BACE1 inhibitors containing pyridine derivatives
Significance of interaction of BACE1-Arg235 with its ligands and design of BACE1 inhibitors
Chemical Synthesis of 71-meric Neuregulin 1-β1
Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue
Development of Biotin-Tagged Tubulin Photoaffinity Probes Derivatized from Diketopiperazine Based Anti-Microtubule Agents
Efficient Total Synthesis of (+)-Negamycin and Its Derivatives
Small Peptide-based Medicinal Chemistry for Intractable Disease
A Synthetic Method for Monodehydro-Cyclic-Dipeptides toward Natural Product Synthesis
New Aspects of Potent Anti-Microtubule Agents Phenylahistin and Tubulin Photoaffinity Labeling
P-518 DEVELOPMENT OF POTENT ANTI-MICROTUBULE AGENTS BASED ON NATURAL DIKETOPIPERAZINE PHENYLAHISTIN AND TUBULIN PHOTOAFFINITY LABELING
Delivery of small interfering RNA with a synthetic collagen poly (Pro-Hyp-Gly) for gene silencing in vitro and in vivo
Atelocollagen-mediated systemic administration of myostatin-targeting siRNA improves muscular atrophy in caveolin-3-deficient mice
Design and Preparation of the Tetrapeptides as Low Molecular Sized BACE1 Inhibitors
Development of a Solid-supported Biotinylation Reagent for the Efficient Biotin Labeling to the SH group of Peptides and Small Molecules
Design of BACE1 Inhibitors Containing 5-Nitro-Isophthalamide
Can the substrate of an enzyme turn into its inhibitor by vastly-reduced k_ value?
Phenyl(cyclo)alkylamines : Second generation P_1' position analogs for pentapeptidic BACE1 inhibitors
Tripeptidic BACE1 Inhibitors by Conformational Structure-based Design
Structure Activity Relationship Study of SARS Coronavirus 3CL Protease Inhibitors with an Electrophilic Aryl Ketone Structure
Synthesis and Biological Evaluation of Dipeptidic Antibiotics (+)-Negamycin and Its Derivatives for Development of Duchenne Muscular Dystrophy Chemotherapy
Development of Chemical Probes towards the Elucidation of Binding Mechanism of Plinabulin, a Cyclicdipeptide Based Anti-microtubule Agent
Novel BACE1 inhibitors containing P_1-P_1' non-natural amino acid-guanidinyl analogues
Design, Synthesis and Evalution of Tripeptidomimetics with Arylketone as Inhibitors of SARS-CoV 3CL Protease
Design and SAR Study of Tripeptidic BACE1 Inhibitors
Development of (+)-Negamycin Derivatives with Potent Readthrough Activity for Duchenne Muscular Dystrophy Chemotherapy

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