Relationship between Structure and Papain Inhibitory Activity of Epoxysuccinyl Amino Acid Derivatives
スポンサーリンク
概要
- 論文の詳細を見る
A number of amino acid derivatives of DL-trans-epoxysuccinic acid, with a general formula of R1O-ES-AA-OR2 (ES, DL-trans-epoxysuccinyl group; AA, amino acid residue) were newly synthesized and used for the study of structure-activity relationships of papain inhibition. Branched-alkyl amino acids, such as Leu, Ile and Val, as AA and hydrogen or an alkyl group substituted with a phenyl or cycloalkyl group as R1 were desirable for activity, respectively. However, R2 or the optical activities of ES and AA not so much influenced on the activity.
- 社団法人 日本農芸化学会の論文
著者
-
Hanada Kazunori
Research Center Taisho Pharmaceutical Co. Ltd.
-
Morimoto Shigeo
Research Center Of Taisho Pharmaceutical Co. Ltd.
-
Tamai Masaharu
Research Center Taisho Pharmaceutical Co. Ltd.
-
Adachi Takashi
Research Center Taisho Pharmaceutical Co. Ltd.
-
MORIMOTO Shigeo
Research Laboratories of Taisho Pharmaceutical Co., Ltd.
-
OHZEKI Masahiro
Research Laboratories of Taisho Pharmaceutical Co., Ltd.
-
OGUMA Kiyoshi
Research Center, Taisho Pharmaceutical Co., Ltd.
-
OGUMA Kiyoshi
Research Laboratories of Taisho Pharmaceutical Co., Ltd.
-
OHMURA Sadafumi
Research Laboratories of Taisho Pharmaceutical Co., Ltd.
-
HANADA Kazunori
Research Laboratories of Taisho Pharmaceutical Co., Ltd.
関連論文
- A Novel Fungal Metabolite NG-061 Enhances and Mimics Neurotrophic Effect of Nerve Growth Factor (NGF) on Neurite Outgrowth in PC12 Cells
- Waol B, a New Trihydrofuran Derivative with Cytocidal Activity, isolated from Mlyceliophthora lutea
- PA145 NOVEL N^6-SUBSTITUTED ADENOSINE WITH CEREBRAL PROTECTING ACTIVITIES ISOLATED FROM MI HUAN JUN
- Synthesis and Antibacterial Activity of the Tricyclic Ketolides TE-802 and Its Analogs
- PI-220, a New Platelet Aggregation Inhibitor
- PROLONGATION OF LIFE SPAN OF DYSTROPHIC HAMSTER BY CYSTEINE PROTEINASE INHIBITOR, LOXISTATIN (EST)
- 2-Acetylpyrrole, a Hepatoprotective Compound from Streptomyces sp. A-5071(Biological Chemistry)
- Late Type Apoptosis and Apoptosis Free Lethal Effect of Quercetin in Human Melanoma
- Application of Cyclodextrin to Microbial Transformation of Vitamin D_3 to 25-Hydroxyvitamin D_3 and 1α, 25-Dihydroxyvitamin D_3
- IN VITRO AND IN VIVO INHIBITION OF CYSTEINE PROTEINASES BY EST, A NEW ANALOG OF E-64
- Introduction of a 50 kbp DNA Fragment into the Plastid Genome
- PA126 STUDY ON THE HEPATOPROTECTIVE CONSTITUENTS OF CANARIUM ALBUM
- Numerical simulation of katabatic wind at Mizuho Station, East Antarctica
- Analytical solutions of katabatic wind at Mizuho and Syowa Station, Antarctica
- The action of chlorphenesin carbamate on the frog spinal cord.
- Immunopharmacologic profiles of a thiol protease inhibitor, L-trans-dicyclohexyl epoxysuccinate.
- Relationship between Structure and Papain Inhibitory Activity of Epoxysuccinyl Amino Acid Derivatives