Enhanced Production of Antibiotics by Pecilomyces lilacinus under Alkaline Conditions Associated with Morphological Change(Microbiology & Fermentation Industry)

概要

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The production of the group of peptide antibiotics called No. 1907 by Paecilomyces lilacinus was stabilized and enhanced by mono-spore isolation followed by strain improvement, and the production seemed to be related to a morphological change of the strain. Unstable and low productivity (below 10μg/ml) of the antibiotics No. 1907 by P. lilacinus was greately improved up to 140μg/ml by successive mono-spore isolation along with mutagenization. Alkaline conditions caused by adding Na_2CO_3, K_2CO_3, NaHCO_3 or KHCO_3 were essential to obtain high production of the antibiotics following simultaneous morphological change of the cells from filamentous mycelia to round arthroconidia. Resting cell experiments showed that a significant amont of antibiotics (213μg/ml) was synthesized by the filamentous cells along with their morphological change to arthroconidia in the presence of glucose under the alkaline conditions.
社団法人日本農芸化学会の論文
1991-02-23