Expression of Differentiation-related Markers in Teratocarcinoma Cells via Histone Hyperacetylation by Trichostatin A(Biological Chemistry)
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概要
- 論文の詳細を見る
The effects of trichostatin A (TSA), a potent and specific inhibitor of mammalian histone deacetylase, on mouse teratocarcinoma cell (F9) differentiation were investigated. TSA caused marked changes in the morphology of cells and stimulated the production of plasminogen activator within 24 hr depending on de novo synthesis of RNA and protein. During the initial 6 hr of incubation, a significant accumulation of hyperacetylated histone species was observed. These results suggest that histone acetylation due to inhibition of the deacetylase is involved in the early stage of morphological and biological differentiation induced by TSA.
- 社団法人日本農芸化学会の論文
- 1991-06-23
著者
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Yoshida Minoru
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University School of Medicine
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Hoshikawa Yutaka
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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BEPPU Teruhiko
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tok
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KIJIMA Masako
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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Kijima Masako
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Beppu Teruhiko
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Yoshida Minoru
Department Of Chemistry St. Marianna University School Of Medicine
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Yoshida Minoru
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Yoshida Minoru
Department Of Agricultural Chemistry Faculty Of Agriculture Iwate University
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