A Case Study on Cyclosporine A in a Patient with Acute Hepatitis
スポンサーリンク
概要
- 論文の詳細を見る
The relationship between the pharmacokinetics of Cyclosporine A (CyA) and the hepatic function was studied in a 15-year-old woman with hepatitis. At the early stage of treatment, the values of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and total serum bilirubin (t-Bil) were higher than the normal range, suggesting hepatic cell injury and impaired bile formation and/or duct. The blood concentration ratio of CyA metabolites (Met) to CyA was markedly decreased from 1.92 to 0.74 in accordance with the clinical improvement in liver function. In addition a significant positive correlation was demonstrated between the Met/CyA ratio and GOT (r = 0.621, p < 0.05), GPT (r = 0.678, p < 0.02) and t-Bil (r = 0.824, p < 0.001), while no significant correlation were found In the concentration-to-dosage ratio of CyA and Met. These results suggest the Met/CyA ratio could be a useful Indicator for evaluate the clinical response and/or hepatic function. We would like to report this as a typical case that presented on apparent correlation of Met/CyA with liver functions. These results also indicate that the Met level as well as the unchanged CyA level should be evaluated in the hepatitis patient.
- 日本医療薬学会の論文
- 1995-10-10
著者
-
Yoshida Minoru
Department of Thoracic and Cardiovascular Surgery, Wakayama Medical University School of Medicine
-
Kihira K
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
-
Kihira Kenji
Department Of Pharmaceutical Services Hiroshima University Hospital : Division Of Clinical Pharmaceu
-
Kihira Kenji
Department Of Pharmaceutical Services Hiroshima University Hospital
-
Miyake Katsushi
Department Of Pharmaceutical Services Hiroshima University Hospital
-
KIMURA Yasuhiro
Department of Biophysics, Kanazawa University School of Medicine
-
KITAURA Teruaki
Department of Pharmaceutical Services, Hiroshima University Hospital
-
FUKUCHI Hiroshi
Department of Pharmaceutical Services, Hiroshima University Hospital
-
Fukuchi Hiroshi
Department Of Clinical Radiology Faculty Of Health Sciences Hiroshima International University
-
Kitaura Teruaki
Department Of Pharmacy Chugoku Central Hospital
-
Kimura Yasuhiro
Department Of Pharmaceutical Services Hiroshima University Hospital : Division Of Clinical Pharmacot
-
KADOYAMA MASAYUKI
Department of Pharmaceutical Services, Hiroshima University Hospital
-
Kadoyama Masayuki
Department Of Pharmaceutical Services Hiroshima University Hospital
-
Kimura Y
Towada Urologic Hospital Towada Jpn
-
Yoshida Minoru
Department Of Chemistry St. Marianna University School Of Medicine
-
Kimura Yasuhiro
Department Of Biophysics Kanazawa University School Of Medicine
-
Yoshida Minoru
Department Of Pharmaceutical Services Hiroshima University Hospital
-
Yoshida Minoru
Department Of Agricultural Chemistry Faculty Of Agriculture Iwate University
-
KIMURA Yasuhiro
Department of Applied Chemistry, Faculty of Engineering, Kanagawa University
関連論文
- PE-516 Asessment of Graft Patency to Analyze the Waveform Using a Fast Fourier Transformation(PE087,Cardiovascular Surgery/CABG (IHD),Poster Session (English),The 73rd Annual Scientific Meeting of the Japanese Circulation Society)
- A Family with Von Hippel-Lindau Disease Revealed by Pheochromocytoma
- MOLECULAR GENETICS OF THE KIDNEY CANCERS ; IMPLICATION OF THE VHL TUMOR SUPPRESSOR GENE
- GERMLINE MUTATIONS IN THE VON HIPPEL-LINDAU DISEASE GENE IN JAPAN ; ITS EPIDEMIOLOGY AND MOLECULAR GENETIC STUDY
- A Large-scale, Hospital-based Case-Control Study of Risk Factors of Brast Cancer According to Menopausal Status
- Detection of germline deletions using real-time quantitative polymerase chain reaction in Japanese patients with von Hippel-Lindau disease
- Germ-line Mutation Analysis in Patients with von Hippel-Lindau Disease in Japan: An Extended Study of 77 Families
- Hairy cell leukemia responsive to anti-thymocyte globulin used as immunosuppressive therapy for aplastic anemia
- Structure-activity Relationship for FR901464 : A Versatile Method for the Conversion and Preparation of Biologically Active Biotinylated Probes
- Short-step Syntheses of All Stereoisomers of Preussin and Their Bioactivities(Organic Chemistry)
- Radicicol Binding to Swo1/Hsp90 and Inhibition of Growth of Specific Temperature-sensitive Cell Cycle Mutants of Fission Yeast(Biochemistry & Molecular Biology)
- Identification of Radicicol as an Inhibitor of In Vivo Ras/Raf Interaction with the Yeast Two-hybrid Screening System
- Identification of Preussin as a Selective Inhibitor for Cell Growth of the Fission Yeast ts Mutants Defective in Cdc2-Regulatory Genes
- Morphology of Ras- Transformed Cells Becomes Apparently Normal Again with Tyrosine Kinase Inhibitors without a Decrease in the Ras- GTP Complex^1
- Phosphatidylinositol-3 Kinase in Fission Yeast : A Possible Role in Stress Responses
- Basidifferquinone Analogues, Basidifferquinone B and C, Which Induce Fruiting-body Formation of a Basidiomycete, Favolus arcularius
- Radicicol, an Agent Inducing the Reversal of Transformed Phenotypes of src-Transformed Fibroblasts
- Basidifferquinone, a New Inducer for Fruiting-body Formation of a Basidiomycetes Favolus arcularius from a Streptomyces Strain II. Structure of Basidifferquinone(Organic Chemistry)
- Basidifferquinone, a New Inducer for Fruiting-body Formation of a Basidiomycetes Favolus arcularius from a Streptomyces Strain I. Screening and Isolation(Organic Chemistry)
- Expression of Differentiation-related Markers in Teratocarcinoma Cells via Histone Hyperacetylation by Trichostatin A(Biological Chemistry)
- Self-Starting Pulse Generation from Cooled Erbium-Doped Fiber Ring Laser(Lasers, Quantum Electronics)
- FIXATION OF HYDROXY ALUMINOSILICATE IONS (PROTO-IMOGOLITE) ON SMECTITE
- Discrete acetylcholine release from neuroblastoma or hybrid cells overexpressing choline acetyltransferase into the neuromuscular synaptic cleft
- Bile Salt Composition and Distribution of the D-Cysteinolic Acid Conjugated Bile Salts in Fish
- Absorption, Biliary Excretion, and Metabolism of a New Cholelitholytic Agent, Ursodeoxycholyl N-Carboxymethylglycine and Its Esters in Rats
- INTESTINAL ABSORPTION AND METABOLISM OF NORCHOLIC ACID IN RATS
- An Improved Simultaneous Measurement of Oxidized and Reduced Glutathione in Biological Samples by High-Performance Liquid Chromatography Following Derivatization with Dansyl Chloride
- Pharmacokinetic Interaction of Zonisamide in Rats. Effect of Other Antiepileptics on Zonisamide
- Pharmacokinetic Analysis of Amitriptyline and Its Demethylated Metabolite in Serum and Brain of Rats after Acute and Chronic Oral Administration of Amitriptyline
- Ocular Pharmacokinetics of Latamoxef and Cefaclor in Humans. Penetration into Aqueous Humor
- Ocular Pharmacokinetics of Latamoxef and Cefaclor in Rabbits. Penetration into Aqueous Humor
- GEX1 Compounds, Novel Antitumor Antibiotics Related to Herboxidiene, Produced by Streptomyces sp. : II. The Effects on Cell Cycle Progression and Gene Expression
- Evaluation of Poly(vinyl alcohol)-Gel Spheres Containing Chitosan as Dosage Form to Control Gastrointestinal Transit Time of Drugs
- MOLECULAR CLONING AND CHARACTERIZATION OF A RAT CHROMATIN-ASSOCIATED PROTEIN, UKp68(Cell Biology and Morphology & Developmental Biology)(Proceedings of the Seventy-Third Annual Meeting of the Zoological Society of Japan)
- Activation of Mitochondrial ATP-Dependent Protease by Peptides and Proteins
- Bilateral testicular tumors in androgen insentitivity syndrome
- Interstitial pneumonitis induced by bicalutamide and leuprorelin acetate for prostate cancer
- The Mechanisms by Which Latanoprost Free Acid Inhibits Human Carbonic Anhydrase I and II(Biochemistry)
- Timolol Activates the Enzyme Activities of Human Carbonic Anhydrase I and II
- Original MRE-binding Transcriptional Factor Gene in Normal Humans is ZRF, not MTF-1
- Prevention of Nephrotoxicity of Cisplatin by Repeated Oral Administration of Ebselen in Rats
- Induction of a Ribotoxic Stress Response That Stimulates Stress-Activated Protein Kinases by 13-Deoxytedanolide, an Antitumor Marine Macrolide
- Japanese Hospital Pharmacists Concepts of Pharmacy in the Year 2010
- ALPHA-ADRENOLYTIC PROPERTIES OF APOGALANTHAMINE AND AZAPETINE ANALOGS
- Nucleocytoplasmic Shuttling of the Aryl Hydrocarbon Receptor^1
- Self-activation of Serine/Threonine Kinase AfsK on Autophosphorylation at Threonine-168
- Detoxication Treatment for Carbamazepine and Lithium Overdose
- Gatifloxacin Induces Augmented Insulin Release and Intracellular Insulin Depletion of Pancreatic Islet Cells(Highlighted paper selected by Editor-in-chief,Molecular and Cell Biology)
- Daily Cost of Ophthalmic Solutions for Treating Glaucoma in Japan
- A Case Study on Cyclosporine A in a Patient with Acute Hepatitis
- Advantage of Body Surface Area on Dose Adjustment of Antiepileptic Drugs
- P-1 Staining Properties of Pridylazodiphenylimidazoles in Histochemical Staining of Metals
- Differentiation of Interfering Metals in Histochemical Staining of Rare Earth Metals with Bromopyridylazodiethylaminophenol
- P-27 Histochemical staining of chromium with 2-(8-quinolylazo)-4,5-ditolylimidazole
- STUDIES ON CHRONIC TOXICITY OF THE LOW LEVELS OF O, O-DIMETHYL O-(3-METHYL-4-NITROPHENYL) PHOSPHOROTHIONATE (SUMITHION) IN THE RAT
- Cessation of Cytokinesis in Schizosaccharomyces pombe during Growth after Release from High Hydrostatic Pressure Treatment
- Synthesis of Cyclic Tetrapeptides Containing Non-natural Imino Acids
- 浅間火山1783年(天明)活動噴出物のフッ素,塩素含有量
- Spectrograph Using the Zone Plate as a Dispersing Element
- A Selective Modulation Interference Spectrometer
- Acute Mercury Poisoning by Intentional Ingestion of Mercuric Chloride
- Synthesis and Activity of Cyl-1 Analogs Having Hydroxamic Acid at Side Chain
- Histone Deacetylase Inhibitors Based on Trapoxin B
- Conformational Analysis of Non-Natural LDLD-Type Cyl-1 Analog with High Activity
- Deep Level Transient Spectroscopy of Bulk Traps and Interface States in Si MOS Diodes
- Three Leucine-Rich Sequences and the N-Terminal Region of Double-Stranded RNA-Activated Protein Kinase (PKR) Are Responsible for Its Cytoplasmic Localization^1
- THE RELATION BETWEEN MERCURY LEVELS IN BRAIN AND BLOOD OR CEREBROSPINAR FLUID(CSF) AFTER MERCURY EXPOSURE (The 6th Meeting for the Study of Toxic Effect)
- Leptomycin, an antifungal and antitumor Streptomyces metabolite, is a novel chemical probe for eukaryotic nucleo-cytoplasmic transport
- The Relationship between Treatment Time of Gemcitabine and Development of Hematologic Toxicity in Cancer Patients
- Blood and Urinary Levels of Metals ( Pb, Cr, Cd, Mn, Sb, Co and Cu ) in Cloisonne Workers
- A Novel Synthesis of Poly(germyl ether) by Regioselective Polyaddition of Dichlorogermane with Bisepoxide
- Indirect AAS Determination of Iodide at the 10^ moll^ Level by Distillation of Iodine Followed by Its Reaction with Arsenic(III)
- Chemical Deposition of Mo on Si
- On Nelson processes with boundary condition
- Molecular mechanism for cell cycle inhibition by biologically active microbial products : Signal transduction and cell cycle : (S-9)
- Multivariate analysis of Japanese volcanic rocks : Volatile and major elements
- Composition and Behavior of Aluminum Ions and Colloidal Aluminosilicates in Acidified Terrestrial Waters
- Placental to Fetal Transfer of Mercury and Fetotoxicity
- Which is the best method to estimate the actual ureteral length in patients undergoing ureteral stent placement?
- Effects of 3-O-Methyldopa, L-3,4-Dihydroxyphenylalanine Metabolite, on Locomotor Activity and Dopamine Turnover in Rats
- Environmentally Stable Ytterbium-Doped Fiber Pulse Laser Composed of All-Polarization-Maintaining Fiber System with a Broad Tuning Range
- The Mechanisms of Insulin Secretion and Calcium Signaling in Pancreatic β-Cells Exposed to Fluoroquinolones
- Two Cases of Acute Myeloid Leukemia Evolving into a Chronic Myelomonocytic Leukemia-like State after Induction Therapy.
- The Fluorine, Chlorine, Bromine, and Iodine Contents of Volcanic Rocks in Japan
- The Photometric Determination of Minute Amounts of Iodine in Silicate Rocks
- Life-style in Relation to the Risk of Breast Cancer*
- Trichostatin C, a New Inducer of Differentiation of Friend Leukemic Cells
- Hygromycin A and Methoxyhygromycin, Novel Inhibitors of K88 Antigen Synthesis of Enterotoxic Escherichia coli Strain
- Effects of genetic variants in SLC22A2 organic cation transporter 2 and SLC47A1 multidrug and toxin extrusion 1 transporter on cisplatin-induced adverse events