Detoxication Treatment for Carbamazepine and Lithium Overdose
スポンサーリンク
概要
- 論文の詳細を見る
This article reports detoxication treatments of a case of combined overdose of carbamazepine and lithium in a 38-year-old female with bipolar disorder. She was brought to the emergency unit after the family found her unresponsive and lying near empty packages for carbamazepine (corresponded to 7.7 g) and lithium carbonate (corresponded to 6.6 g) tablets. On admission, her blood pressure, heart rate and respiratory rate were 80/55 mmHg, 90 per minute and 13 per minute, respectively. Her GCS was 3 (E1, M1, V1). She received gastric lavage after intratracheal intubation, followed by administration of activated charcoal via gastric tube, and a large volume (800 ml/h) of lactate Ringer's solution by intravenous infusion. The serum levels of carbamazepine and lithium approximately 5 h after ingestion were 56.0 μg/ml and 3.56 mEq/l, respectively. The carbamazepine overdose was mainly treated by a 3 h charcoal hemoperfusion (CHP). The CHP treatment decreased serum carbamazepine levels by approximately 30-40% as compared with the levels simulated by Bayesian analysis using 1-point or 2-points serum level(s) (without detoxication treatment). For lithium overdose continuous infusion of Ringer's solution was effective, which increased serum sodium gradually and facilitated the elimination of lithium. In conclusion, the treatments with CHP and continuous infusion of Ringer's solution were considered to be effective for detoxification of carbamazepine and lithium overdose, respectively, when compared with those drug levels without detoxication treatment that simulated by Bayesian analysis method.
- 公益社団法人日本薬学会の論文
- 2008-01-01
著者
-
木平 健治
Department of Pharmaceutical Services, Hiroshima University Hospital
-
谷川 攻一
広島大学大学院救急医学
-
Ikeda Hiroaki
Department Of Medical Oncology Kkr Sapporo Medical Center
-
Kihira Kenji
Department Of Pharmaceutical Services Hiroshima University Hospital : Division Of Clinical Pharmaceu
-
Kihira Kenji
Department Of Pharmaceutical Services Hiroshima University Hospital
-
Tanigawa Koichi
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
-
MURAKAMI Teruo
Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima I
-
Ikeda Hiroaki
Department Of Cancer Vaccine Mie University Graduate School Of Medicine
-
UNEI Hiroko
Department of Pharmaceutical Services, Hiroshima University Hospital
-
Unei Hiroko
Department Of Pharmaceutical Services Hiroshima University Hospital
-
Tanigawa Koichi
Department Of Advanced Emergency And Critical Care Center Hiroshima University Hospital
-
Murakami Teruo
Laboratory Of Biopharmaceutics And Pharmacokinetics Faculty Of Pharmaceutical Sciences Hiroshima Int
-
Ikeda Hiroaki
Department Of Pharmaceutical Services Hiroshima University Hospital
-
谷川 攻一
広島大学病院 高度救命救急センター・集中治療部
-
池田 博昭
Department of Pharmaceutical Services, Hiroshima University Hospital
-
村上 照夫
Laboratory of Biopharmaceutics and Pharmacokinetics, Faculty of Pharmaceutical Sciences, Hiroshima International University
-
畝井 浩子
Department of Pharmaceutical Services, Hiroshima University Hospital
-
谷川 攻一
Department of Advanced Emergency and Critical Care Center, Hiroshima University Hospital
関連論文
- ICUにおけるヒヤリ・ハット事例に関するアンケート調査
- Regional Characteristics of [^I] Cholecystokinin Octapeptide Specific Binding to Rat Brain Membranes Following 6-Hydroxydopamine Treatment
- Effects of L-DOPA on Cholecystokinin Octapeptide Tissue Levels in Normal and 6-Hydroxydopamine-Treated Rat Brain
- Changes of Cholecystokinin Octapeptide Tissue Levels in Rat Brain Following Dopamine Neuron Lesions Induced by 6-Hydroxydopamine
- PJ-449 The efficacy of new stent delivery technique : slip through technique(Coronary revascularization, PCI(20)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-554 Usefulness of Transient Ischemic Dilation in Adenosine Stress Myocardial Perfusion SPECT for Detection of Three-Vessel Coronary Artery Disease(Nuclear cardiology(06)(I),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circ
- 地学教員養成のための練習船の利用 (総特集 水産系大学学部練習船--現状と将来)
- Tetramer-blocking assay for defining antigen-specific cytotoxic T lymphocytes using peptide-MHC tetramer
- 26pS-3 二次元格子イジングスピン反強磁性体Rb_2Co_Mg_xF_4のμSR
- PJ-266 Efficacy of Prospective ECG Triggered Algorithm With Low-dose Radiation Exposure Using 64-slice Computed Tomographic Coronary Angiography(CT/DSA(08)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-070 Comprehensive Characterization of Non-Calcified Coronary Plaque Using 64-Slice Computed Tomography in Patients with Acute Coronary Syndrome(CT/DSA(07)(I),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Societ
- PE-272 Atorvastatin Therapy Decreases Lipid-Rich Coronary Plaques as Detected by 64-Slice Computed Tomographic Angiography(Atherosclerosis, clinical(06)(IHD),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- OE-158 Reliability of Non-Calcified Coronary Plaque Findings by 64-Slice Computed Tomography Compared with Intravenous Ultrasound(CT/DSA(01)(I),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PE-402 Noninvasive Detection of Obstructive Coronary Artery Disease Using Calcium Score : Analysis in Different Age Spans and Genders(Chronic coronary heart disease/Remodeling-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PE-220 Comprehensive Assessment of Coronary Plaque Vulnerability with 64-Slice Computed Tomography(CT/DSA-05, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 鹿児島湾の湾口断面を通しての海水流入・流出過程
- Spin Dynamics in Two-Dimensional Percolating Heisenberg Antiferromagnets
- 鹿児島湾口を通しての海水の流入・流出過程
- Mechanical Injury of the Subthalamic Area During Stereotactic Surgery Followed by Improvement of Trunk, Neck, and Face Tremor : Case Report
- Efficacy of Navigation in Skull Base Surgery using Composite Computer Graphics of Magnetic Resonance and Computed Tomography Images
- Phase I study of amrubicin and vinorelbine in non-small cell lung cancer previously treated with platinum-based chemotherapy
- Analysis of the response and toxicity to gefitinib of non-small cell lung cancer
- Fourth-Order Perturbation Expansion for Hubbard Model on a Two-Dimensional Square Lattice(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Theory of Superconductivity in CeMIn_5 (M=Co, Rh, Ir) on the Basis of the Three Dimensional Periodic Anderson Model(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Fourth Order Perturbation Theory for Normal Selfenergy in Repulsive Hubbard Model(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Calculation of Penetration Depth and T_c in κ-(ET)_2Cu(NCS)_2 under Pressure(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Theory of Superconductivity in PuCoGa_5 (Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Possible Pairing Symmetry of Superconductor Na_xCoO_2・yH_2O (Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- PJ-621 Feasibility and Optimization of Aortic Valve Planimetry Using Retrospective ECG-gated 64-slice Multidetector-Row Computed Tomography(PJ104,CT/MRI (Myocardium) 3 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circul
- PJ-258 Nonobstructive Aortic Valve Calcification and Cardiovascular Risk Factors as Predictors of Coronary Artery Atherosclerosis Assessed by 64-slice Multidetector-row Computed Tomography(PJ044,Atherosclerosis (Clinical/Diagnosis) 2 (IHD),Poster Session
- PE-184 Lower High Molecular Weight Adiponectin Level is Associated with Unstable Coronary Plaques as Detected by Multi-detecter Computed Tomography(PE031,Metabolic Syndrome 2 (H),Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese
- PE-073 Evaluation of Coronary Calcium and Noncalcified Plaque Characteristics in Patients with Acute Coronary Syndrome by Multislice Computed Tomography(PE013,CT/MRI (Coronary/Vascular) (I),Poster Session (English),The 73rd Annual Scientific Meeting of Th
- OJ-208 Usefulness of 64-slice Multidetector-Row Computed Tomography in the Simultaneous Evaluation of Aortic Valve Area and Coronary Artery Disease(OJ35,Valvular Heart Disease/Pericarditis/Cardiac Tumor 1 (M),Oral Presentation (Japanese),The 73rd Annual S
- OE-157 Coronary Plaque Stabilization by Intensive Statin Therapy Decreasing Serum LDL/HDL Cholesterol Ratio on Multislice Computed Tomographic Angiography(OE27,CT/MRI (Coronary/Vascular) 1 (I),Oral Presentation (English),The 73rd Annual Scientific Meeting
- 3 Characterization of Noncalcified Coronary Plaques and Prediction of Culprit Lesions in Patients with Acute Coronary Syndrome by 64-Slice Computed Tomography(A New Horizon of Cardiac CT-Beyond Lumen Visualization-,Symposium 13 (SY-13) (IHD),The 73rd Annu
- 3 Visceral Fat Accumulation as a Predictor of Coronary Artery Calcium and Vulnerable Plaques as Assessed by Multislice Computed Tomography(Key Players of Metabolic Syndrome,Symposium 4 (SY-04) (M),The 73rd Annual Scientific Meeting of The Japanese Circula
- PJ-862 Is an Initial Shock Energy Level of 200 J Appropriate for Ventricular Fibrillation with Use of Monophasic Defibrillators ?(Emergency care / CPR(05)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-366 Excessive Lactic Acid and Hyperkalemia are Associated with Survival Rate in Patients with In-hospital Cardiopulmonary Arrest(Emergency care-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Analysis of Superconductivity Induced by On-site Coulomb Repulsion on Three-dimensional Cubic Lattice : Based on Third Order Perturbation Theory
- Possible Mechanism of Superconductivity in Ce-Based Heavy Fermion Compounds : Analysis Based on the Third-Order Perturbation Theory
- Study of Superconductivity in Borocarbides on the Basis of Perturbation Theory
- Monte Carlo Study on the Nuclear Magnetic Ordering in Scandium Crystal:Possibility of a Ferrimagnetic State
- An indispensable role of type-1 IFNs for inducing CTL-mediated complete eradication of established tumor tissue by CpG-liposome co-encapsulated with model tumor antigen
- 1α,25-Dihydroxyvitamin D3 downmodulates the functional differentiation of Th1 cytokine-conditioned bone marrow-derived dendritic cells beneficial for cytotoxic T lymphocyte generation
- STAT6-mediated signaling in Th2-dependent allergic asthma : critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation
- The critical role of type-1 innate and acquired immunity in tumor immunotherapy
- 「日本集中治療医学会専門医研修施設のリスクマネージメント委員会の活動状況とICUの関与」ならびに「事故抜管などのICUにおけるインシデントの現状と予防対策」に関するアンケート調査
- Predictive value of expression of P53, Bcl-2 and lung resistance-related protein for response to chemotherapy in non-small cell lung cancers
- Mucou Gland Adenoma of the Trachea Resected with an Endoscopic Neodymium: Yttrium Aluminum Garnet Laser
- Lymphoproliferative Disorder of Granular Lymphocytes (Natural Killer Cell Type) with Interstitial Pneumonia in a Patient with Familial Pancytopenia
- Chronic Lymphocytic Leukemia Associated with Nephrotic Syndrome and Dermatomyositis
- Inductively Coupled Plasma Mass Spectrometry for the Determination of Platinum Accumulation in Human Non-Small Cell Lung Cancer Cell Lines
- "Web-like Obstruction" - A Sign of Regional Complete Remission after Concurrent Chemoradiotherapy in Small Cell Lung Cancer
- Bile Salt Composition and Distribution of the D-Cysteinolic Acid Conjugated Bile Salts in Fish
- Absorption, Biliary Excretion, and Metabolism of a New Cholelitholytic Agent, Ursodeoxycholyl N-Carboxymethylglycine and Its Esters in Rats
- INTESTINAL ABSORPTION AND METABOLISM OF NORCHOLIC ACID IN RATS
- Possibility of f-Wave Spin-Triplet Superconductivity in the CoO_2 Superconductor : A Case Study on a 2D Triangular Lattice in the Repulsive Hubbard Model
- Perturbation Theory on the Superconductivity of Heavy Fermion Superconductors CeIr_xCo_In_5
- Analysis of Superconductivity in d-p Model on Basis of Perturbation Theory(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Perturbation Analysis of Superconductivity in the Trellis-Lattice Hubbard Model(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Perturbation Theory for a Repulsive Hubbard Model in Quasi-One-Dimensional Superconductors (Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Phase II Study of Gefitinib Readministration in Patients with Advanced Non-Small Cell Lung Cancer and Previous Response to Gefitinib
- Synthesis of Polymer Microspheres with Mercapto Groups by Polycondensation of 1,3-Propanedithiol and 1,6-Dibromohexane in the Presence of a Poly[styrene-alkylacrylamide] Latex
- Evaluation of Clinical Efficacy of Maeda's Nomogram for Vancomycin Dosage Adjustment in Adult Japanese MRSA Pneumonia Patients
- The Mechanisms by Which Latanoprost Free Acid Inhibits Human Carbonic Anhydrase I and II(Biochemistry)
- Timolol Activates the Enzyme Activities of Human Carbonic Anhydrase I and II
- 16-6 OPRICAL-FIBER DATA TRANSMISSION SYSTEM FOR PFM AUDIO SIGNAL
- Detoxication Treatment for Carbamazepine and Lithium Overdose
- Gatifloxacin Induces Augmented Insulin Release and Intracellular Insulin Depletion of Pancreatic Islet Cells(Highlighted paper selected by Editor-in-chief,Molecular and Cell Biology)
- Daily Cost of Ophthalmic Solutions for Treating Glaucoma in Japan
- A Case Study on Cyclosporine A in a Patient with Acute Hepatitis
- Advantage of Body Surface Area on Dose Adjustment of Antiepileptic Drugs
- Electronic Structure and Magnetic and Optical Properties of NiAs-type Transition-Metal Chalcogenides MX (M=Fe, Co; X=S, Se)
- DBS RECEIVER UTILIZING OPTICAL FIBER AS INTERMEDIATE FREQUENCY TRANSMISSION LINE
- OPTICAL FIBER TWO-WAY FM VIDEO SIGNAL TRANSMISSION FOR VIDEO CONFERENCING APPLICATIONS
- Glucocorticoid-induced tumor necrosis factor receptor stimulation enhances the multifunctionality of adoptively transferred tumor antigen-specific CD8^+ T cells with tumor regression
- Head-to-head comparison of the cardio-ankle vascular index between patients with acute coronary syndrome and stable angina pectoris
- Potential of Selected Strains of Lactic Acid Bacteria to Induce a Th1 Immune Profile
- Possibility of f-Wave Spin-Triplet Superconductivity in the CoO_2 Superconductor : A Case Study on a 2D Triangular Lattice in the Repulsive Hubbard Model(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)
- Vernet's Syndrome Caused by Large Mycotic Aneurysm of the Extracranial Internal Carotid Artery After Acute Otitis Media : Case Report
- Phase II Study of Irinotecan plus S-1 Combination for Previously Untreated Advanced Non-Small Cell Lung Cancer: Hokkaido Lung Cancer Clinical Study Group Trial (HOT) 0601
- Interplay of Crystal Field Structures with f^2 Configuration to Heavy Fermions(Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- True Meaning of "Localized" f-Electrons Measured by dHvA Experiments in Ce-Based Heavy Fermion Metals (Condensed Matter: Electronic Structure, Electrical, Magnetic and Optical Properties)
- A Theory of Anisotropic Semiconductor of Heavy Fermions
- Compressibility of Rodlike and Coiled Polymers in Solution
- Pseudogap and Superconductivity in Iron-Based Layered Superconductor Studied by Fluctuation-Exchange Approximation(Condensed matter: electronic structure and electrical, magnetic, and optical properties)
- Compressibility of Polymer in Solution in the MHz Range
- Fermi-Surface Evolution by Transition-Metal Substitution in the Iron-based Superconductor LaFeAsO
- Association Between Plasma High-Molecular-Weight Adiponectin and Coronary Plaque Characteristics Assessed by Computed Tomography Angiography in Conditions of Visceral Adipose Accumulation
- Study of Superconductivity in Borocarbides on the Basis of Perturbation Theory
- Is Fermi-Surface Nesting the Origin of Superconductivity in Iron Pnictides?: A Fluctuation–Exchange-Approximation Study
- Erratum: "Pseudogap and Superconductivity in Iron-Based Layered Superconductor Studied by Fluctuation–Exchange Approximation"
- Erratum: "Possible Mechanism of Superconductivity in Ce-Based Heavy Fermion Compounds: Analysis Based on the Third-Order Perturbation Theory"
- Calculation of Penetration Depth and T_c in κ-(ET)_2Cu(NCS)_2 under Pressure(Condensed Matter : Electronic Structure, Electrical, Magnetic and Optical Properties)