Analysis of the response and toxicity to gefitinib of non-small cell lung cancer

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概要

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• Background: Gefitinib is an oral agent that inhibits the tyrosine kinase of epidermal growth factor receptor (EGFR), which had antitumor activity in patients with previously treated non-small cell lung cancer (NSCLC). We analyzed the efficacy, toxicitiy, and overall survival time of gefitinib in patients with NSCLC.Patients and Methods: One hundred and twenty-two patients with NSCLC who received gefitinib between 2002 and 2004 in our institutes were evaluated retrospectively.Results: The objective response rate was 24.6%. The variables identified as significant in univariate analysis included gender and smoking habit. The median overall survival time was 14.4 months. Significant variables associated with improved survival included good performance status (PS), female, adenocarcinoma and never smoked status, and never smoked status and good PS were independent prognostic factors in multivariate analysis. Four patients (3.3%) developed interstitial pneumonitis associated with gefitinib.Conclusion: Gefitinib showed favorable anti-tumor activity in females, never smokers and adenocarcinoma.

• International Institute of Anticancer Researchの論文

著者

• Oizumi S

  First Department Of Medicine Hokkaido University School Of Medicine

• Oizumi Satoshi

  北海道大学 医学部第一内科学

• Oizumi Satoshi

  First Department Of Medicine Hokkaido University School Of Medicine

• Nishimura M

  First Department Of Medicine Hokkaido University School Of Medicine

• Yokouchi Hiroshi

  First Department Of Medicine Hokkaido University School Of Medicine

• 池田 宏信

  鹿児島大学工学部

• Ikeda Hiroaki

  Department Of Medical Oncology Kkr Sapporo Medical Center

• Nakashima M

  Department Of Molecular Immunology And Clinical Immunology Medical Institute Of Bioregulation Kyushu

• Ikeda H

  Department Of Science Kyoto University

• 池田 宏信

  高エネルギー研

• Dosaka-akita H

  Department Of Medical Oncology Hokkaido University Graduate School Of Medicine

• Ikeda Hironobu

  Fukuoka Agricultural Research Center

• Ikeda Hironobu

  Neutron Science Laboratory Institute Of Materials Structure Science High Energy Accelerator Research

• Ikeda Hiroaki

  Fac. Of Medicine Mie Univ.

• Konishi Jun

  First Department Of Medicine Hokkaido University School Of Medicine

• Nakashima M

  Kyushu Univ. Fukuoka Jpn

• ISHIDA Takashi

  the First Department of Medicine, Hokkaido University School of Medicine

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