Clinical characteristics of pleomorphic carcinoma of the lung
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概要
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Background: Pleomorphic carcinoma of the lung is a malignant epithelial tumor that contains carcinomatous and sarcomatoid components. Due to its rarity, few studies have been reported, and its clinical and pathological characteristics remain unclear. Method: We retrospectively investigated 22 cases of pleomorphic carcinoma of the lung. Results: Fifteen cases were diagnosed by surgical resection, four by autopsy, and three by transbronchial biopsy. Nineteen patients were male and three were female, and their mean age at diagnosis was 68.3 years (± 10.1). Eighteen were current- or ex-smokers with substantial smoking histories (mean 46.4 pack-years). Sixteen patients had symptoms: hemoptysis and cough were commonly seen. Chest computed tomography (CT) findings revealed that the tumors were quite large (mean diameter 45.3 ± 21.9 mm; range 14-110 mm), and 21 tumors were peripherally located. Positron emission tomography with 18-fluorodeoxy-glucose (FDG-PET) was performed in 12 patients, and the Standardized Uptake Value (SUV) tended to be high (9.44 ± 4.98). In the 15 patients who underwent surgical resection, recurrence was common; systemic metastases were also frequently found. Patients who had received surgical treatment with proper follow-up care survived longer than those who did not undergo surgery. Responses to chemotherapy were generally poor, although one patient exhibited partial response to gefitinib. Conclusions: Pulmonary pleomorphic carcinoma has strong malignant potential with frequent distant metastases, as has already been reported. However, this study demonstrated that surgical treatment and appropriate follow-up therapy might result in better prognoses.
著者
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Oizumi S
First Department Of Medicine Hokkaido University School Of Medicine
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Oizumi Satoshi
北海道大学 医学部第一内科学
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Oizumi Satoshi
First Department Of Medicine Hokkaido University School Of Medicine
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Nishimura M
First Department Of Medicine Hokkaido University School Of Medicine
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Yokouchi Hiroshi
First Department Of Medicine Hokkaido University School Of Medicine
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Nakashima M
Department Of Molecular Immunology And Clinical Immunology Medical Institute Of Bioregulation Kyushu
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Nakashima M
Kyushu Univ. Fukuoka Jpn
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ISHIDA Takashi
the First Department of Medicine, Hokkaido University School of Medicine
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Harada Toshiyuki
First Department Of Medicine Hokkaido University School Of Medicine
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- Clinical characteristics of pleomorphic carcinoma of the lung
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