Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis

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概要

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• Background: Mannose receptor (MR) is a member of the C-type lectin receptor family involved in pathogen molecular-pattern recognition and thought to be critical in shaping host immune response. The aim of this study was to investigate potential associations of genetic variants in the MRC1 gene with sarcoidosis. Methods: Nine single nucleotide polymorphisms (SNPs), encompassing the MRC1 gene, were genotyped in a total of 605 Japanese consisting of 181 sarcoidosis patients and 424 healthy controls. Results: Suggestive evidence of association between rs691005 SNP and risk of sarcoidosis was observed independent of sex and age in a recessive model (P = 0.001). Conclusions: These results suggest that MRC1 is an important candidate gene for sarcoidosis. This is the first study to imply that genetic variants in MRC1, a major member of the C-type lectin, contribute to the development of sarcoidosis.

• 2010-10-28

著者

• Nishimura M

  First Department Of Medicine Hokkaido University School Of Medicine

• Huang Shau

  Johns Hopkins Asthma And Allergy Center

• Nakashima M

  Department Of Molecular Immunology And Clinical Immunology Medical Institute Of Bioregulation Kyushu

• HATTORI Takeshi

  First Department of Medicine, Hokkaido University School of Medicine

• Nakashima M

  Kyushu Univ. Fukuoka Jpn

• Hizawa Nobuyuki

  Department Of Pulmonary Medicine Graduate School Of Comprehensive Human Sciences University Of Tsukuba

• Takahashi Ayumu

  First Department Of Medicine Hokkaido University School Of Medicine

• Isada Akira

  First Department Of Medicine Hokkaido University School Of Medicine

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