A functional polymorphism in the RANTES gene promoter is associated with the development of late-onset asthma.

スポンサーリンク

概要

• 論文の詳細を見る

• The CC chemokine regulated upon activation, normal T-cell expressed and secreted (RANTES) attracts eosinophils, basophils, and T cells during inflammation and immune response, indicating a possible role for this chemokine in asthma. Both the -403A and -28G alleles of the RANTES promoter region exhibit significantly enhanced promoter activity in reporter constructs in vitro. We therefore investigated the genetic influence of these alleles on the development of asthma using case-control analysis in a Japanese population (298 patients with asthma and 311 control subjects). Given the evidence for heterogeneity of asthma according to age at onset, we divided patients with asthma into three subgroups: 117 late-onset patients with asthma (onset at more than 40 years of age), 83 middle-onset patients with asthma (onset at 20 to 40 years of age), and 98 early-onset patients with asthma (onset at less than 20 years of age). The -28G allele was significantly associated with late-onset asthma (odds ratio = 2.033; 95% confidence interval, 1.379–2.998; corrected p < 0.0025) but was not associated with the other two asthma subgroups. The -403A allele was not associated with any of the asthma subgroups. Further evidence of the importance of the -28G allele was a significant increase in the production of RANTES in vitro in individuals who carried this allele. Our findings suggest that, among Japanese, the -28G allele of the RANTES promoter region confers susceptibility to late-onset asthma.

• American Thoracic Society (ATS)の論文
• 2002-09-01

著者

• Nishimura M

  First Department Of Medicine Hokkaido University School Of Medicine

• Tanino Yoko

  First Department Of Medicine Hokkaido University School Of Medicine:johns Hopkins Asthma And Allergy

• Hizawa Nobuyuki

  Department Of Pulmonary Medicine Graduate School Of Comprehensive Human Sciences University Of Tsukuba

関連論文

• Clinical characteristics of pleomorphic carcinoma of the lung
• Combining transbronchial biopsy using endobronchial ultrasonography with a guide sheath and positron emission tomography for the diagnosis of small peripheral pulmonary lesions
• Comparison of the Pharmacodynamics of Biapenem in Bronchial Epithelial Lining Fluid in Healthy Volunteers Given Half-Hour and Three-Hour Intravenous Infusions
• Genetic variants in mannose receptor gene (MRC1) confer susceptibility to increased risk of sarcoidosis
• Airflow limitation and airway dimensions assessed per bronchial generation in older asthmatics
• Steep dose-response relationship for stage I non-small cell lung cancer using hypo-fractionated high-dose irradiation by real-time tumor-tracking radiotherapy (RTRT)
• Expression and Diagnostic Evaluation of the Human Tumor-Associated Antigen RCAS1 in Pancreatic Cancer
• Construction of the Single-Chain Fv from 196-14 Antibody toward Ovarian Cancer-Associated Antigen CA125
• Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer
• HLA class I antigen expression is associated with a favorable prognosis in early stage non-small cell lung cancer
• Tetramer-blocking assay for defining antigen-specific cytotoxic T lymphocytes using peptide-MHC tetramer
• Expression of RCAS1 in human gastric carcinoma : A potential mechanism of immune escape
• CD4^+ T cells in cancer stroma, not CD8^+ T cells in cancer cell nests, are associated with favorable prognosis in human non-small cell lung cancers
• Expression of Human Tumor-Associated Antigen RCAS1 in Adult T-Cell Leukemia/Lymphoma
• Expression of Apoptosis-Associated Protein RCAS1 in Macrophages of Histiocytic Necrotizing Lymphadenitis
• Airflow limitation and airway dimensions in chronic obstructive pulmonary disease.
• Chemokines in bronchiolar epithelium in the development of chronic obstructive pulmonary disease.
• Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid.
• Phase I study of amrubicin and vinorelbine in non-small cell lung cancer previously treated with platinum-based chemotherapy
• Non-responsiveness to gefitinib in a patient with lung adenocarcinoma having rare EGFR mutations S768I and V769L.
• Establishment and characterization of amylase-producing lung adenocarcinoma cell line, IMEC-2.
• Analysis of the response and toxicity to gefitinib of non-small cell lung cancer
• Paraneoplastic Cerebellar Degeneration (PCD) Associated with Squamous Cell Carcinoma of the Lung
• Genetic Impact of a Butyrophilin-like 2 (BTNL2) Gene Variation on Specific IgE Responsiveness to Dermatophagoides farinae (Der f) in Japanese
• Osteopontin : A Potential Biomarker for Successful Bee Venom Immunotherapy and a Potential Molecule for Inhibiting IgE-mediated Allergic Responses
• Polymorphisms in the muscarinic receptor 1 gene confer susceptibility to asthma in Japanese subjects.
• 2 Identification of a new candidate gene (Osteopontin) for regulating the IgE production through the use of cDNA microarray analysis(II. Asthma Genetics)
• Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy.
• A functional polymorphism in the RANTES gene promoter is associated with the development of late-onset asthma.
• A common FCER1B gene promoter polymorphism influences total serum IgE levels in a Japanese population.
• Levels of Transferrin in Bronchoalveolar Lavage Fluid in Sarcoidosis
• Pharmacokinetics of telithromycin using bronchoscopic microsampling after single and multiple oral doses
• Epithelioid sarcoma presenting as pulmonary cysts with cancer antigen 125 expression
• Susceptibility to oxygen desaturation during bronchoscopy in elderly patients with pulmonary fibrosis
• Bronchoscopic microsampling method for measuring drug concentration in epithelial lining fluid
• Predictive value of expression of P53, Bcl-2 and lung resistance-related protein for response to chemotherapy in non-small cell lung cancers
• Increased Apoptosis Associated with Depressed Type of Early Intestinal Gastric Cancer
• Relationship Between Diseased Lung Tissues on Computed Tomography and Motion of Fiducial Marker Near Lung Cancer
• Phase II Study of Gefitinib Readministration in Patients with Advanced Non-Small Cell Lung Cancer and Previous Response to Gefitinib
• Comparison of airway remodelling assessed by computed tomography in asthma and COPD
• Phase II Study of Irinotecan plus S-1 Combination for Previously Untreated Advanced Non-Small Cell Lung Cancer: Hokkaido Lung Cancer Clinical Study Group Trial (HOT) 0601
• Virtual bronchoscopic navigation combined with endobronchial ultrasound to diagnose small peripheral pulmonary lesions : a randomised trial
• A Case of Follicular Bronchiolitis Associated with Asthma, Eosinophilia, and Increased Immunoglobulin E
• Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer
• CD8+ tumor-infiltrating lymphocytes predict favorable prognosis in malignant pleural mesothelioma after resection
• Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis
• The Peptide Nucleic Acid-Locked Nucleic Acid Polymerase Chain Reaction Clamp-Based Test for Epidermal Growth Factor Receptor Mutations in Bronchoscopic Cytological Specimens of Non-Small Cell Lung Cancer
• Expression of Bim, Noxa, and Puma in non-small cell lung cancer
• A functional polymorphism (-603A→G) in the tissue factor gene promoter is associated with adult-onset asthma

もっと見る 閉じる

スポンサーリンク