Studies on Antibiotics Produced at High Alkaline pH
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概要
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Screening by using high alkaline media was carried out to detect new antibiotics produced by alkalophilic and alkali-resistant microorganisms. Three thousand strains of microorganisms, mainly fungi and streptomycetes, were isolated on high alkaline media (pH 10.3). The microorganisms consisted of 1206 strains of streptomycetes, 1511 strains of fungi and 283 strains of bacteria. Among these strains, 151 strains of streptomycetes, 148 strains of fungi and 36 strains of bacteria showed antimicrobial activities. One strain of alkalophilic streptomycetes, Streptomyces sp. No. 1543, produced antimycin A. An alkali-resistant fungi, strain No. 401, identified as Verticillium lecanii, produced helvolic acid. An alkalophilic fungi, strain No. 1907, identified as Paecilomyces lilacinus, produced a group of homologous new peptide antibiotics, Nos. 1907-II to VIII, in a broth fermented under the high alkaline conditions.
著者
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Arima Kei
Department Of Agricultural Chemistry University Of Tokyo
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Beppu Teruhiko
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Arima Kei
Department of Agricultural Chemistry, The University of Tokyo
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SATO Michikatsu
Department of Agricultural Chemistry, The University of Tokyo
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