Comparative Study on the Specificities of Several Fungal Aspartic and Acidic Proteinases towards the Tetradecapeptide of a Renin Substrate(Biological Chemistry)
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概要
- 論文の詳細を見る
The tetradecapeptide of a renin substrate, DRVYIHPFHLLVYS, was used as a substrate for assaying several fungal aspartic and acidic proteinases in the acidic pH range. Aspartic and acidic proteinases from Phycomycetes, Mucor and Rhizopus, and Deuteromycotina, Aspergillus and Penicillium, cleaved the tetradecapeptide at its tyrosyl^4-isoleucyl^5 (Y^4_I^5), histidyl^6-proly^7 (H^6_P^7) and leucyl^<11>-valyl^<12> (L^<11>-V^<12>) bonds in the acidic pH range, while acidic proteinases type B and type A-I from Scytalidium lignicolumn, and those from Cladosporium and Basidiomycetes, Pycnoporus sanguineus, and the yeast, Rhodotorula glutinis, showed slightly different specificities towards the tetradecapeptide. Pepsin primarily cleaved the valyl^3-tyrosyl^4 (V^3-Y^4) and leucyl^<10>-leucyl^<11> (L^<10>-L^<11>) bonds. All of the aspartic and acidic proteinases of fungal origin tested in the present study have different specificities from that of pepsin.
- 社団法人日本農芸化学会の論文
- 1988-03-23
著者
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ODA Kohei
Department of Applied Biology, Kyoto Institute of Technology
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ICHISHIMA EIJI
Department of Bioengineering, Graduate School of Engineering, Soka University
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Ichishima E
Department Of Bioengineering Graduate School Of Engineering Soka University
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Ichishima Eiji
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Murao Sawao
Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture
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Murao S
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Oda K
National Research Inst. Brewing Tokyo Jpn
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Oda Kohei
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Murao Sawao
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Majima Eiji
Laboratory Of Enzymology And Microbial Chemistry Tokyo University
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Ichikawa Eiji
Gekkeikan Research Institute Gekkeikan Sake Co. Ltd.
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