Purification and Some Properties of an Inhibitor for a Yeast Pleiotropic Drug Resistant Pump from Kitasatospora sp. E-420(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
A strain producing an inhibitor for pleiotropic drug resistant 5 (Pdr5) was isolated using our original screening system in yeast. The strain was classified and named as Kitasatospora sp. E-420. The purified inhibitor (molecular weight = 1,193 by FAB-MS) inhibited a Pdr5-mediated efflux of cycloheximide and cerulenin. The intracellular accumulation of a fluorescent dye, rhodamine 123, by the inhibitor was also confirmed. Some physicochemical data suggested that the Pdr5-specific inhibitor was different from an immunosuppressant, FK506, reported as the only inhibitor of Pdr5 in vivo.
- 社団法人日本農芸化学会の論文
- 2001-10-23
著者
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Hiraga Kazumi
Department of Applied Biology, Kyoto Institute of Technology
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ODA Kohei
Department of Applied Biology, Kyoto Institute of Technology
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Hiraga K
Kyoto Inst. Technol. Kyoto Jpn
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Hiraga Kazumi
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Hiraga K
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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WANIGASEKERA Anoja
Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology
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HAMANAKA Nobuyuki
Department of Applied Biology, Faculty of Textile Science, Kyoto Institute of Technology
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Oda Kohei
Department Of Agricultural Chemistry College Of Agriculture University Of Osaka Prefecture
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Oda K
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Hamanaka Nobuyuki
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Wanigasekera Anoja
Department Of Applied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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