Inhibition of α-Amylase and Phosphorylases by Cyclodextrin-Dialdehyde(Biological Chemistry)
スポンサーリンク
概要
- 論文の詳細を見る
Dialdehyde derevatives of cyclodextrin (dial-CD) were prepared by the periodate oxidation method. The dial-CD inhibited not only exo-type amylases (β-amylase and glucoamylase) but also endo-type α-amylase, and the degree of inhibition was much stronger than that with the corresponding native cyclodextrin (CD). α-Glucan phosphorylases from muscle, yeast, and potato were also inhibited by the dial-CD and the resulting Ki values for the muscle enzyme were 7〜8-fold lower than those of the native CD. A progressive inactivation of the muscle phosphorylase by the dial-α-CD suggested that this compound would be useful as an affinity-labeling reagent for phosphorylase. Although the dial-CD was less effective for the irreversible inactivation of amylases than the phosphorylase, the potent inhibition of several amylases by the dial-CD would provide an useful inhibitory compond for kinetic analysis.
- 社団法人日本農芸化学会の論文
- 1988-11-23
著者
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Takagi Shiro
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Tanabe Satoshi
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Matsuda Kazuo
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University:(present Office)iwaki-
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Matsuda Kazuo
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Takagi S
Tohoku Univ. Sendai Jpn
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ICHISHIMA EIJI
Department of Bioengineering, Graduate School of Engineering, Soka University
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Ichishima Eiji
Department Of Bioengineering Graduate School Of Engineering Soka University
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Ichishima E
Department Of Bioengineering Graduate School Of Engineering Soka University
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Ichishima Eiji
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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KOBAYASHI Mikihiko
Department of Agricultural Chemistry, Faculty of Agriculture, Tohoku University
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Kobayashi M
Biophotonics Information Laboratories Yamagata Advanced Technology Research And Development Center
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Kobayashi Mikihiko
Jissen Women's Univ.
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Kobayashi Mikihiko
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Matsuda K
Iwaki Meisei Univ. Fukushima Jpn
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KOBAYASHI Masaki
Yamagata Advanced Technology Research and Development Center
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Ichikawa Eiji
Gekkeikan Research Institute Gekkeikan Sake Co. Ltd.
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Matsuda Kazuo
Department Of Agricultural Biochemistry Faculty Of Agriculture Tohoku University
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