Enhanced Production of L(+)-Lactic Acid from Corn Starch in a Culture of Rhizopus oryzae Using an Air-Lift Bioreactor

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概要

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• L(+)-Lactic acid production was investigated using 8 Rhizopus strains and various culture conditions. Rhizopus oryzae NRRL395 showed the highest yield of L(+)-lactic acid among various Rhizopus strains. The optimum production medium contained the following : corn starch, 120 g/l; ammonium sulfate, 1.35 g/l; small amounts of mineral salts (potassium phosphate, magnesium sulfate and zinc sulfate). The data obtained for the flask culture were successfully reproduced using a 3 l air-lift bioreactor under the optimum conditions. The yield (based on initial carbon source concentration) and final concentraion of L(+)-lactic acid were 85% and 102 g/l, respectively, in the 3 l air-lift bioreactor. The lactic acid was recovered with a yield (based on lactic acid containing in broth) of 90% using 4 steps, i.e., filtration, active carbon treatment, ultra-filtration and concentration by vacuum evaporation. The lactic acid purified was 100% L(+)-form as judged by HPLC.

• 社団法人日本生物工学会の論文
• 1997-09-25

著者

• Okabe Mitsuyasu

  Mercian Co. Central Research Laboratories

• Okabe Mitsuyasu

  Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture

• Okabe Mitsuyasu

  (present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University

• Park Y

  Laboratory Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuo

• OKABE Mitsuyasu

  Lab. of Biotechnology, Department of Appl. Biol. Chem. , Shizuoka Univ.

• Okabe M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• YIN PEIMIN

  United Graduate School of Agricultural Science, Gifu University

• YAHIRO KAZUTOYO

  Department of Development, Chikou Co. Ltd.

• NISHINA NAOKI

  Lab. of Biotechnology, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka

• KOSAKAI YUUKO

  Lab. of Biotechnology, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka

• PARK YONGSOO

  Lab. of Biotechnology, Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka

• Yin Peimin

  United Graduate School Of Agricultural Science Gifu University

• Kosakai Yuuko

  Lab. Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Uni

• Nishina Naoki

  Lab. Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Uni

• Yahiro Kazutoyo

  Department Of Development Chikou Co. Ltd.

• Okabe Mitsuyasu

  Lab. Of Biotechnology Department Of Appl. Biol. Chem. Shizuoka Univ.

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