Optimization and Scale-Up of L-Lactic Acid Fermentation by Mutant Strain Rhizopus sp. MK-96-1196 in Airlift Bioreactors (BIOCHEMICAL ENGINEERING)

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概要

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• We determined the optimum culture conditions such as inoculum size, initial starch concentration, pH during the fermentation and aeration rate for L-lactic acid production by Rhizopus sp. MK-96-1196 in a 3-l airlift bioreactor. More than 90g/l of L-lactic acid was produced from only partially enzymatically hydrolyzed corn starch with a production rate of 2.6g/l/h and a product yield of 87% based on the starch consumed under the optimum conditions in the 3-l airlift bioreactor. Scale-up from the 3-l to a 100-l airlift bioreactor for L-lactic acid fermentation was carried out using V_s (cm/s) as a scale-up criterion. The production rates and yields of L-lactic acid in both bioreactors appeared to be fairly well correlated with k_la(1/h).

• 社団法人日本生物工学会の論文
• 2003-07-25

著者

• Dwiarti L

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Mercian Co. Central Research Laboratories

• Okabe Mitsuyasu

  Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture

• Okabe Mitsuyasu

  (present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University

• Kojima M

  Japan And Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• MIURA SHIGENOBU

  Tokyo Laboratories, Musashino Chemical Laboratory Ltd.

• Miura Shigenobu

  Tokyo Laboratories Musashino Chemical Laboratory Ltd.

• Arimura Tomohiro

  Tokyo Laboratories Musashino Chemical Laboratory Ltd.

• Okabe M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

• HOSHINO MINAKO

  Tokyo Laboratories, Musashino Chemical Laboratory Ltd.

• KOJIMA MAMI

  Japan and Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

• DWIARTI LIES

  Japan and Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

• OKABE MITSUYASU

  Japan and Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

• Hoshino Minako

  Tokyo Laboratories Musashino Chemical Laboratory Ltd.

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