Scale-Up of L-Lactic Acid Production by Mutant Strain Rhizopus sp. MK-96-1196 from 0.003m^3 to 5m^3 in Airlift Bioreactors(BIOCHEMICAL ENGINEERING)
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概要
- 論文の詳細を見る
In order to study the feasibility of commercial-scale L-lactic acid production by Rhizopus sp. MK-96-1196 using large scale airlift bioreactors (ALBs), a scale-up study from 0.003m^3 to 5m^3 ALB was carried out using oxygen transfer rate (OTR) as the scale-up criterion. Enhanced L-lactic acid production was achieved at OTRs higher than 0.28 (g-O_2/l/h) irrespective of the scale of the bioreactor in question : in the range of 0.003m^3 to 5m^3, more than 90g/l L-lactic acid was produced with a yield of approximately 80%, based on the initial glucose concentration. In future research, we plan to design an ALB greater than 3000m^3 (working volume : 2000m^3) for further studies on the production of L-lactic acid in large quantities.
- 社団法人日本生物工学会の論文
- 2006-01-25
著者
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OKABE MITSUYASU
Department of Applied Biological Chemistry, Faculty of agriculture, Shizuoka University
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Okabe Mitsuyasu
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Okabe Mitsuyasu
Mercian Co. Central Research Laboratories
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Okabe Mitsuyasu
Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer
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Okabe Mitsuyasu
Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University
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Okabe Mitsuyasu
Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture
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Okabe Mitsuyasu
(present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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MIURA SHIGENOBU
Tokyo Laboratories, Musashino Chemical Laboratory Ltd.
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Miura Shigenobu
Tokyo Laboratories Musashino Chemical Laboratory Ltd.
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Arimura Tomohiro
Tokyo Laboratories Musashino Chemical Laboratory Ltd.
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Okabe M
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Liu Tiejun
The United Graduate School of Agricultural Science, Gifu University
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Yaguchi Masaaki
Tokyo Laboratories, Musashino Chemical Laboratory Ltd.
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Park Enock
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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Tiejun Liu
The United Graduate School Of Agricultural Science Gifu University
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Park Enock
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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Yaguchi Masaaki
Tokyo Laboratories Musashino Chemical Laboratory Ltd.
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