Effect of Soybean Oil on Oxygen Transfer in the Production of Tetracycline with an Airlift Bioreactor
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概要
- 論文の詳細を見る
Corn starch and soybean oil are suitable carbon sources for the production of tetracycline by Streptomyces aureofacience CG-1. However, it could not produce more than 6 g/l of tetracycline even if initial corn starch concentration was increased to more than 100 g/l. It was confirmed by shaking flask experiments that the k_La in a mixture of 2% soybean oil in water was four folds compared with that without soybean oil. With the addition of soybean oil to the starch medium in a shaking flask, tetracycline production was significantly improved. By scaling-up to a 5.5-l airlift bioreactor from 500-ml Erlenmeyer flask, more than 10 g/l of tetracycline was produced with the addition of 60 g/l of soybean oil to the medium containing 100 g/l of corn starch. The dissolved oxygen level in the airlift bioreactor containing soybean oil was higher than that without soybean oil. This suggests that soybean oil is not only a suitable carbon source but is also a surface-active agent which may accelerate the oxygen transfer. This may lead to the possibility of the enhanced production of tetracycline at a low cost in airlift bioreactor.
- 社団法人日本生物工学会の論文
- 1999-06-25
著者
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OKABE MITSUYASU
Laboratory of Biotechnology, Department of Applied Biological Chemistry, Faculty of Agriculture, Shi
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Choi Du
Institute Of Life Science Chosun University
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Kahar P
Gifu Univ. Gifu Jpn
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Kahar Prihardi
United Graduate School Of Agricultural Science Gifu University
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Kahar Prihardi
Laboratory Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuo
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JIA SHIRU
Department of Biochemical Engineering, Tianjin University of Light Industry
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CHEN GUIBIN
Department of Biochemical Engineering, Tianjin University of Light Industry
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Jia S
Tianjin Univ. Light Ind. Tianjin Chn
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Jia Shiru
Department Of Biochemical Engineering Tianjin University Of Light Industry
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Chen Guibin
Department Of Biochemical Engineering Tianjin University Of Light Industry
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Okabe Mitsuyasu
Laboratory Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuo
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Okabe Mitsuyasu
Mercian Co. Central Research Laboratories
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Okabe Mitsuyasu
Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer
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Okabe Mitsuyasu
Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University
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Okabe Mitsuyasu
Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture
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Okabe Mitsuyasu
(present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University
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Okabe M
Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University
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