Optimization of Tylosin Feeding Rate Profile in Production of Acetyl-Isovaleryl Tylosin(AIV)from Tylosin by Streptomyces thermotolerans YN554

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概要

• 論文の詳細を見る

• An optimal feed rate profile of a substrate(tylosin)for a novel antibiotic, acetyl-isovaleryl tylosin(AIV)production process was investigated. In the first step of optimization, a kinetic model for production of AIV from tylosin by Streptomyces thermotolerans was established properly using the least square method, followed by the confirmation that the proposed model could be used to predict the production process of AIV from tylosin. An objective function, state equations and an inequality constraint with respect to the tylosin feeding rate profile were applied to maximize the amount of AIV produced from tylosin in a fed-batch culture. The optimized tylosin feeding rate profile was determined using a direct iterative search algorithm based on the modified complex method. The simulation of AIV production at the optimal tylosin feeding profile indicates that the final amount of AIV is expected to be about 30% higher than that at the conventional constant tylosin feeding rate, which was also confirmed experimentally using a 30-l jar fermentor.

• 社団法人日本生物工学会の論文
• 2001-05-25

著者

• OKABE MITSUYASU

  Laboratory of Biotechnology, Department of Applied Biological Chemistry, Faculty of Agriculture, Shi

• Kahar P

  Gifu Univ. Gifu Jpn

• Kahar Prihardi

  United Graduate School Of Agricultural Science Gifu University

• HUANG GUOWEI

  United Graduate School of Agricultural Science, Gifu University

• TSUNEKAWA HIROSHI

  Mercian Corporation

• PARK YONGSOO

  Laboratory of Biotechnology, Department of Applied Biological Chemistry, Faculty of Agriculture, Shi

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuo

• Okabe Mitsuyasu

  Mercian Co. Central Research Laboratories

• Okabe Mitsuyasu

  Biotechnology Lab. Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka Univer

• Okabe Mitsuyasu

  Laboratory Of Biotechnology Faculty Of Agriculture Shizuoka University

• Okabe Mitsuyasu

  Biochemical Engineering Laboratory Department Of Applied Biological Chemistry Faculty Of Agriculture

• Okabe Mitsuyasu

  (present Address)department Of Applied Biochemistry Faculty Of Agriculture Shizuoka University

• Huang G

  United Graduate School Of Agricultural Science Gifu University

• Huang Guowei

  United Graduate School Of Agricultural Science Gifu University

• Park Y

  Laboratory Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuo

• Park Yongsoo

  Laboratory Of Biotechnology Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuo

• Okabe M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Shizuoka University

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• Optimization of Tylosin Feeding Rate Profile in Production of Acetyl-Isovaleryl Tylosin(AIV)from Tylosin by Streptomyces thermotolerans YN554
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