Itaconic Acid Production Using an Air-Lift Bioreactor in Repeated Batch Culture of Aspergillus terreus

概要

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Repeated itaconic acid production using an air-lift bioreactor was carried out by three methods-two with cell recyling be means of centrifugation and filtration by a statinless steel filter set inside the bioreactor and one by repeated batch culture witout cell recycling. In a flask, repeated itaconic acid production was stable for 9 cycles (45 d) and the production rate was 0.47 g/l/h. However, in the air-lift bioreactor, it was difficult to produce itaconic acid in the repeated batch culture with cell recycling for a long period due to a decreased in fluidity resulting from an increase in mycelium concentration. In the method without cell recycling, however, repeated itaconic acid production was stable for 4 cycles (21 d) and the production rate was 0.37 g/l/h.
社団法人日本生物工学会の論文
1994-03-25