Screening and Production of Arylsulfatases for Target Therapy with Etoposide 4'-Sulfate,an Antitumor Prodrug
スポンサーリンク
概要
- 論文の詳細を見る
Two arylsulfatase-producing streptomycetes that desulfated etoposide 4'-sulfate were isolated from soil samples. Taxonomical study identified one soil isolate as Streptomyces griseorubiginosus S980-14 (Es-1 arylsulfatase producer), while the other was considered new and tentatively designated Streptomyces sp. T109-3 (Es-2 arylsulfatase producer). Both strains produced extracellular arylsulfatase activities, provided that cultivation media were prepared with distilled water. Unlike the two known types of arylsulfatases, which had significant activity on p-nitrophenyl sulfate but none on etoposide 4'-sulfate, the crude streptomycete arylsulfatases efficiently desulfated etoposide 4'-sulfate and p-nitrophenyl sulfate, which supports the establishment of a new type of arylsulfatases.
- 社団法人日本農芸化学会の論文
- 1995-06-23
著者
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Tomita Koji
Bristol-myers Squibb Research Institute
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Sawada Y
Dept. Of Appl. Biol. Sci. Nihon University:(present Office)riken Psc
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Ueki Tomokazu
Bristol-Myers Squibb Research Institute
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Sawada Yosuke
Bristol-Myers Squibb Research Institute
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Fukagawa Yasuo
Bristol-Myers Squibb Research Institute
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Oki Toshikazu
Bristol-Myers Squibb Research Institute
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Yamamoto Satoshi
Bristol-Myers Squibb Research Institute
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Ohnuma Takeshi
Bristol-Myers Squibb Research Institute
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Oki Toshikazu
Bristol-myers Squibb Research Institute Ltd. Tokyo Research Center
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Ohnuma Takeshi
Laboratory Of Protein Chemistry And Engineering Graduate School Of Bioresource And Environmental Sci
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Fukagawa Yasuo
Bristol-myers Squibb Research Institute Ltd. Tokyo Research Center
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Fukagawa Yasuo
Central Research Laboratories Sanraku Incorporated
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Yamamoto Syuji
Institute For Life Science Research Asahi Chemical Industry Co. Ltd.
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YAMAMOTO SATOSHI
Marine Biotechnology Institute, Kamaishi Laboratories
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Tomita Katsuhisa
Research Institute Fancl Co.
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Sawada Y
Bristol-myers Squibb Research Institute:funakoshi Co. Ltd. Life Science Products Division
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Yamamoto S
Fuso Pharmaceutical Ind. Ltd. Osaka Jpn
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