Protective Effect of Eurystatins A and B, New Prolyl Endopeptidase Inhibitors, on Scopolamine-Induced Amnesia in Rats.

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概要

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• Eurystatins A and B, which are produced by <I>Streptomyces eurythermus</I> R353-21, potently inhibited <I>Flavobacterium</I> prolyl endopeptidase (PED) with IC<SUB>50</SUB> values of 0.004 and 0.002 μg/ml, respectively, while no inhibition was observed against another 5 proteases, even at 100 μg/ml. The protective effect of eurystatins A and B against scopolamine (3 mg/kg, i.p.)-induced amnesia in rats was evaluated by the step-through one-trial passive avoidance method. When administered i.p. 30 min prior to the acquisition trial, both eurystatins A, at 2-8 mg/kg, and B, at 4-8 mg/kg, significantly protected rats from the amnesic effect of scopolamine without behavioral side effects.

• 公益社団法人 日本薬理学会の論文

著者

• Ueki Tomokazu

  Bristol-Myers Squibb Research Institute

• Fukagawa Yasuo

  Bristol-Myers Squibb Research Institute

• Oki Toshikazu

  Bristol-Myers Squibb Research Institute

• KAMEI Hideo

  Bristol-Banyu Research Institute, Ltd.

• Kamei Hideo

  Bristol-Myers Squibb Research Institute

• Obi Yumiko

  Bristol-Myers Squibb Research Institute

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• Protective Effect of Eurystatins A and B, New Prolyl Endopeptidase Inhibitors, on Scopolamine-Induced Amnesia in Rats.

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