Inhibitory effects of copiamycin A, a macrocyclic lactone antibiotic, on gastric H+, K+-ATPase, acid secretion and ulcer formation.
スポンサーリンク
概要
- 論文の詳細を見る
When 17 macrocyclic lactone antibiotics were examined for their abilities to inhibit gastric H<SUP>+</SUP>, K<SUP>+</SUP>-ATPase, copiamycin A was found to have the strongest and relatively specific activity with IC<SUB>50</SUB>s of 15.7 μg/ml and > 100 μg/ml against the hog gastric H<SUP>+</SUP>, K<SUP>+</SUP>-ATPase and the dog kidney Na<SUP>+</SUP>, K<SUP>+</SUP>-APTase, respectively. Furthermore, this antibiotic inhibited the histamine-induced gastric acid secretion in the isolated gastric mucosal membrane of guinea pigs and the gastric ulcer formation in pylorus-ligated rats.
- 公益社団法人 日本薬理学会の論文
著者
-
Oki Toshikazu
Bristol-Myers Squibb Research Institute
-
KAMEI Hideo
Bristol-Banyu Research Institute, Ltd.
-
KAWANO Kimio
Bristol-Banyu Research Institute, Ltd.
-
Kawano Kimio
Bristol-Myers Squibb Research Institute
-
Hamagishi Yasutaro
Bristol-Myers Squibb Research Institute
関連論文
- A New Type of Streptomycete Arylsulfatase with High Affinity to the Sulfuryl Moiety of the Substrate
- Arylsulfatase from Streptomyces griseorubiginosus S980-14
- Screening and Production of Arylsulfatases for Target Therapy with Etoposide 4'-Sulfate,an Antitumor Prodrug
- Siamycins I and II, New Anti-HIV Peptides:I.Fermentation, Isolation, Biological Activity and Initial Characterization
- ANTI-ASTHMATIC ACTIVITY OF BB-1502 BY INHALATION
- PHARMACOLOGICAL STUDIES ON BB-1502, A NEW BRONCHODILATOR
- Inhibitory effects of copiamycin A, a macrocyclic lactone antibiotic, on gastric H+, K+-ATPase, acid secretion and ulcer formation.
- Protective Effect of Eurystatins A and B, New Prolyl Endopeptidase Inhibitors, on Scopolamine-Induced Amnesia in Rats.