Effect of Osmotic Strength on 5'-Inosinic Acid Fermentation in Mutants of Corynebacterium ammoniagenes
スポンサーリンク
概要
- 論文の詳細を見る
The effect of osmotic strength on 5'-inosinic add (IMP) fermentation was examined with a mutant, Corynebacterium ammoniagenes KY10895. The growth of KY10895 was inhibited by increased osmotic strength in the medium, but the specific IMP production (IMP produced/cell density) was promoted. The concentration of L-proline increased greatly under osmotic stress. Mutants resistant to growth inhibition by osmotic strength were derived from KY10895. Strain H-4415 had the highest IMP productivity. The intracellular concentration of L-proline in strain H-4415 was higher than in the parental strain. The addition of an osmoprotectant, betaine, in the production medium did not increase IMP production. These results suggested that the derivation of an osmotolerant stain is an effective method to obtain a hyperproducer of IMP, and that an increase in intracellular L-proline is related to increased IMP production.
- 社団法人日本農芸化学会の論文
- 1992-05-23
著者
-
Tomita Kazuhiro
Technical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.
-
Tomita Koji
Bristol-myers Squibb Research Institute
-
NAKANISHI Toshihide
(Present address) Ube Plant, Kyowa Hakko Kogyo Co., Ltd.
-
KURATSU Yoshiyuki
Technical Research Laboratories, Hofu Plant, Kyowa Hakko Kogyo Co., Ltd.
-
Tomita Katsuhisa
Research Institute Fancl Co.
-
Kuratsu Y
Technical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.
-
Nakanishi T
(present Address) Ube Plant Kyowa Hakko Kogyo Co. Ltd.
関連論文
- Ingestion of Difructose Anhydride III Enhances Absorption and Retention of Calcium in Healthy Men
- Dietary Melibiose Regulates Th Cell Response and Enhances the Induction of Oral Tolerance
- (-)-Hydroxycitric Acid Ingestion Increases Fat Utilization During Exercise in Untrained Women
- Effect of Osmotic Strength on 5'-Inosinic Acid Fermentation in Mutants of Corynebacterium ammoniagenes
- Stimulation by L-Proline of 5'-Inosinic Acid Production by Mutants of Corynebacterium ammoniagenes(Microbiology & Fermentation Industry)
- Screening and Production of Arylsulfatases for Target Therapy with Etoposide 4'-Sulfate,an Antitumor Prodrug
- Pyrrolosporin A, a New Antitumor Antibiotic from Micromonospora sp. C39217-R109-7 I. Taxonomy of Producing Organism, Fermentation and Biological Activity
- Cloning of Oxetanocin A Biosynthetic and Resistance Genes that Reside on a Plasmid of Bacillus megaterium Strain NK84-0128
- Studies of Cosmid Transduction in Streptomyces lividans and Streptomyces parvulus(Microbiology & Fermentation Industry)
- (-)-Hydroxycitrate Ingestion Increases Fat Oxidation during Moderate Intensity Exercise in Untrained Men(Food & Nutrition Science)
- Establishment of a Host-vector System in Bacillus megaterium Strain NK84-0128, an Oxetanocin A Producer
- Dietary Melibiose Regulates Th Cell Response and Enhances the Induction of Oral Tolerance
- Ingestion of Difructose Anhydride III Enhances Absorption and Retention of Calcium in Health Men
- Influence of Carbon Sources on the Stimulatory Effect of L-Proline on 5'-Inosinic Acid Production
- Correlation between Intracellular L-Proline Concentration and IMP Productivity in Corynebacterium ammoniagenes
- Aeration-Agitation Effect on Coenzyme Q_ Production by Agrobacterium species
- Effect of Phosphate Ion and Ammonia-Nitrogen on Colistin Production by Bacillus polymyxa : Studies on Colistin Fermentation (II)
- Effect of Carbon/Nitrogen Ratio and Inorganic Phosphate on Colistin Production
- Isolation and Characterization of a Stable L-Arginine Producer from Continuous Culture Broth of Corynebacterium acetoacidophilum : L-Arginine Production by Continuous Culture (I)
- Control of Broth Viscosity in Colistin Fermentation by Bacillus polymyxa : Studies on Colistin Fermentation(III)
- Effect of AmmoniumIon on Coenzyme Q10 Fermentation by Agrobacterium species
- Productivity and Colony Morphology Associated with Coenzyme Q10 Production by Agrobacterium Species
- Stimulatory Effect of Aspartic Acid on Colistin Production by Bacillus polymyxa