Dietary Melibiose Regulates Th Cell Response and Enhances the Induction of Oral Tolerance
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概要
- 論文の詳細を見る
We examined how dietary melibiose affected the T-helper (Th) cell responses induced by an orally fed antigen in ovalbumin (OVA)-specific T cell receptor transgenic mice (OVA 23-3). Dietary melibiose markedly decreased the Th2 type responses as shown by a significant decrease in the interleukin (IL)-4 production and T cell proliferative response induced by sensitization from the 7-d oral administration of OVA. It was additionally observed that the Th1 type responses tended to decrease. We therefore examined the effect of melibiose feeding on the induction of immunological tolerance induced by the oral administration of an antigen (oral tolerance). The Th cell responses induced in BALB/c mice by subcutaneous immunization with OVA were suppressed by the prior oral administration of OVA. Such responses in the OVA-fed and immunized mice were further diminished by dietary melibiose. These results suggest that dietary melibiose strongly affected the Th cell responses to an ingested antigen, and further demonstrate the potential of melibiose to enhance the induction of oral tolerance.
- 社団法人 日本農芸化学会の論文
著者
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Nagura Taizo
Research Center, Nippon Beet Sugar Mfg. Co., Ltd.
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Aritsuka Tsutomu
Research Center, Nippon Beet Sugar Mfg. Co., Ltd.
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Tomita Kyoko
Research Institute, FANCL Co.
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Okuhara Yasuhide
Research Institute, FANCL Co.
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SHIGEMATSU Norihiro
Research Institute, FANCL Co.
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NAKAJIMA-ADACHI Haruyo
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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HACHIMURA Satoshi
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Tomita Katsuhisa
Research Institute Fancl Co.
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