Stimulation by L-Proline of 5'-Inosinic Acid Production by Mutants of Corynebacterium ammoniagenes(Microbiology & Fermentation Industry)
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概要
- 論文の詳細を見る
The effects of amino acids on IMP production were examined with a mutant strain, KY10895, derived from Corynebacterium ammoniagenes KY13374. L-Proline improved the productivity of IMP more than any other amino acid. The optimum concentration of L-proline for IMP production was 1-2% and the IMP productivity was about 70% more than that in the control medium. The effects of L-proline analogs on IMP production were also examined with the mutant KY109\895. DL-3,4-Dehydroproline inhibited IMP production. Mutants resistant to growth inhibition by DL-3,4-dehydroproline were derived from strain KY10895. Among mutants thus obtained, strain H-7335 had the highest productivity. The intracellular concentrations of L-proline in strain H-7335 were higher than those of the parentalstrain, KY10895. These findings indicated that an increase in intracellular L-proline was linked with an increase of IMP produtivity and strengthening the L-proline synthesis of a strain was an effective method for obtaining a hyper-producer of IMP.
- 社団法人日本農芸化学会の論文
- 1991-09-23
著者
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Tomita Kazuhiro
Technical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.
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Tomita Koji
Bristol-myers Squibb Research Institute
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KURATSU Yoshiyuki
Technical Research Laboratories, Hofu Plant, Kyowa Hakko Kogyo Co., Ltd.
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NAKANISHI Toshihide
Technical Research Laboratories, Hofu Plant, Kyowa Hakko Kogyo Co., Ltd.
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Tomita Katsuhisa
Research Institute Fancl Co.
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Kuratsu Y
Technical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.
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Nakanishi T
(present Address) Ube Plant Kyowa Hakko Kogyo Co. Ltd.
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Nakanishi Toshihide
Technical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.
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