Mechanism for the Stabilization by L-Valine of L-Leucine Fermentation Using an Unstable Mutant of Corynebacterium glutamicum(Microbiology & Fermentation Industry)

概要

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The L-leucine production by an L-leucine producing mutant, H-1204, of Corynebacterium glutamicum was unstable because the strains (M- and V-types) exhibiting reduced L-leucine productivity appeared during cultivation. Stabilization of the L-leucine production was attempted on the basis of the properties of various strains: L-type, an original L-leucine producer (valine leaky strain); M-type, a prototrophic strain; and V-type, a leucine auxotrophic strain. The addition of L-valihe to the medium was found to be most effective. L-Valine had a double effect in that it not only stimulated the growth of the L-type but also inhibited the growth of the V-type as an antagonist as to its leucine uptake. It was also revealed that C. glutamicum has two different transport systems for branched chain amino acids and dipeptides, respectively.
社団法人日本農芸化学会の論文
1988-05-23