Factors Affecting L-Arginine Production in the Continuous Culture of an L-Arginine Producer of Corynebacterium acetoacidophilum : L-Arginine Production by Continuous Culture (II)
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概要
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The effects of culture conditions on L-arginine production by continuous culture were studied using a stable L-arginine hyperproducing strain of Corynebacterium acetoacidophilum, SC-190. Strain SC-190 demonstrated a volumetric productivity of 1.35 g ・l^<-1>・h^<-1> at a dilution rate of 0.083 h^<-1> and feeding sugar concentration of 8%, and a product yield of 29.2% at a dilution rate 0.021 h^<-1> and feeding sugar concentration of 15%. The corresponding values for fed-batch culture are 0.85 g・l^<-1>・h^<-1> and 26%. However, the product yield decreased with an increase in the volumetric productivity. To achieve stable L-arginine production, aeration and agitation conditions sufficient to maintain an optimal level of redox potential (>-100 mV) were necessary. The addition of phosphate to the feeding medium led to a decrease in L-arginine production. It was confirmed in the steady state that growth and L-arginine formation were inhibited by a high concentration of L-arginine.
- 公益社団法人日本生物工学会の論文
- 1988-06-25
著者
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Nakanishi Toshihide
Technical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.
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Azuma Tomoki
Technical Research Laboratories Hofu Plant Kyowa Hakko Kogyo Co. Ltd.
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- Properties of Revertants Appearing in L-Leucine Fermentation Culture Broth(Microbiology & Fermentation Industry)
- Application of L-Glutamate to L-Proline Fermentation by Corynebacterium acetoacidophilum
- Factors Affecting L-Arginine Production in the Continuous Culture of an L-Arginine Producer of Corynebacterium acetoacidophilum : L-Arginine Production by Continuous Culture (II)
- Isolation and Characterization of a Stable L-Arginine Producer from Continuous Culture Broth of Corynebacterium acetoacidophilum : L-Arginine Production by Continuous Culture (I)