Suppression of the Systemic Immune Response to Casein by Oral Administration of a Tryptic Digest of Casein
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概要
- 論文の詳細を見る
The systemic immune response against orally administered antigens is suppressed (oral tolerance), and this has been postulated to avoid excess immunity against dietary constituents which are present in large amounts in the gastrointestinal tract. Taking into consideration that such orally administered protein antigens are subjected to enzymatic degradation in the gastrointestinal tract, we examined whether an enzymatic digest of milk proteins could induce oral tolerance. A tryptic digest of casein, containing mainly fragments smaller than 6000 Da, was fed to mice as a constituent of their diet. Mice fed with the casein-digest diet responded poorly to subsequent immunization with casein, indicating that oral tolerance to casein was induced in these animals. The results suggest the presence of immunosuppressive fragment(s) in the casein digest, which may be of use for preventing milk allergy.
- 社団法人日本農芸化学会の論文
- 1993-10-23
著者
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ENOMOTO Atsushi
Department of Pathology, Nagoya University Graduate School of Medicine
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TAKAHASHI Yoshimasa
Department of Pharmacology, Gifu Pharmaceutical University
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TSUMORI Chiaki
Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women's Medical College
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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HACHIMURA Satoshi
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Takahashi Y
Dep. Of Food Sci. And Nutrition School Of Human Environmental Sciences Mukogawa Women's Univ.
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Kaminogawa Shuichi
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th
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Takahashi Yoshimasa
Department Of Chemistry College Of Science And Engineering Aoyama Gakuin University
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Habu S
Division Of Host Defense Mechanism Department Of Immunology Tokai University School Of Medicine
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Tsumori Chiaki
Department Of Agricultural Chemistry The University Of Tokyo
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Kaminogawa S
Dep. Of Food Sci. And Technol. Nihon Univ.
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Enomoto Atsushi
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Hachimura S
Res. Center For Food Safety Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Fujikawa Yoko
Department of Agricultural Chemistry, The University of Tokyo
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Yoshino Umeo
Department of Nutrition, Tokyo Kasei University
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Hachimura Satoshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Yoshino Umeo
Department Of Nutrition Tokyo Kasei University
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Fujikawa Yoko
Department Of Agricultural Chemistry The University Of Tokyo
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Hachimura Satoshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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