Antigen Presentation by Peyer's Patch Cells Can Induce both Th1- and Th2-type Responses Depending on Antigen Dosage, but a Different Cytokine Response Pattern from That of Spleen Cells(Food & Nutrition Science)

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概要

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• The Th1 and Th2 preference induced by cells from the Peyer's patch (PP) and spleen (SPL) with various doses of an antigen was examined. The same splenic T cell receptor-transgenic CD4^+ T cells were first incubated with PP or SPL cells in the presence of various doses of an antigen, and the cytokine response was observed after secondary stimulation. A Th2-type pattern was only obtained for primary stimulation at 10 μM of the antigen with PP cells, whereas a Th1 pattern was induced at both higher and lower concentrations. SPL cells in the presence of 0.1 to 1 μM of the antigen induced the secretion of Th2-type cytokines. Ten and 100 μM of the antigen plus SPL cells did not induce the release of a large quantity of cytokines. PP cells induced a different cytokine pattern at the antigen concentration that induced a similar level of T cell proliferation with SPL cells. Our findings suggest that the antigendose dependent development of Th1/Th2 cells is differentially modulated by the antigen-presentation function of cells in PP and SPL.

• 社団法人日本農芸化学会の論文
• 2002-05-23

著者

• YOSHIDA Tadashi

  Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University

• KINUGASA Fumitaka

  Department of Immunology, Pharmacology Research Labs, Astellas Pharma, Inc.

• KAMINOGAWA Shuichi

  Department of Food Science and Technology, College of Bioresource Sciences, Nihon University

• HACHIMURA Satoshi

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U

• Yoshida Tadashi

  Dep. Of Applied Biological Sci. Tokyo Univ. Of Agriculture And Technol.

• Kaminogawa Shuichi

  Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th

• AMETANI Akio

  Applied Biological Chemistry, University of Tokyo

• AMETANI Akio

  Department of Applied Biological Chemistry, The University of Tokyo

• Kametani Y

  Applied Biological Chemistry University Of Tokyo

• Ametani Akio

  Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)torrey Pines Ins

• Habu S

  Division Of Host Defense Mechanism Department Of Immunology Tokai University School Of Medicine

• Ishimori Mina

  Department Of Applied Biological Chemistry University Of Tokyo

• TOTSUKA Mamoru

  Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U

• ISE Wataru

  Department of Applied Biological Chemistry, University of Tokyo

• Kaminogawa S

  Dep. Of Food Sci. And Technol. Nihon Univ.

• Totsuka Mamoru

  Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of

• Totsuka M

  Department Of Applied Biological Chemistry The University Of Tokyo

• Totsuka Mamoru

  Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo

• Hachimura S

  Res. Center For Food Safety Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo

• Ise Wataru

  Department Of Applied Biological Chemistry University Of Tokyo

• Yoshida Tadashi

  Department Of Applied Biological Science Faculty Of Agriculture Tokyo University Of Agriculture And

• Kaminogawa Shuichi

  Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo

• Hachimura Satoshi

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Kinugasa Fumitaka

  Department Of Applied Biological Chemistry University Of Tokyo

• Hachimura Satoshi

  Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni

• Yoshida Tadashi

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University:(present Office)frontie

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