Antigen Presentation by Peyer's Patch Cells Can Induce both Th1- and Th2-type Responses Depending on Antigen Dosage, but a Different Cytokine Response Pattern from That of Spleen Cells(Food & Nutrition Science)
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概要
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The Th1 and Th2 preference induced by cells from the Peyer's patch (PP) and spleen (SPL) with various doses of an antigen was examined. The same splenic T cell receptor-transgenic CD4^+ T cells were first incubated with PP or SPL cells in the presence of various doses of an antigen, and the cytokine response was observed after secondary stimulation. A Th2-type pattern was only obtained for primary stimulation at 10 μM of the antigen with PP cells, whereas a Th1 pattern was induced at both higher and lower concentrations. SPL cells in the presence of 0.1 to 1 μM of the antigen induced the secretion of Th2-type cytokines. Ten and 100 μM of the antigen plus SPL cells did not induce the release of a large quantity of cytokines. PP cells induced a different cytokine pattern at the antigen concentration that induced a similar level of T cell proliferation with SPL cells. Our findings suggest that the antigendose dependent development of Th1/Th2 cells is differentially modulated by the antigen-presentation function of cells in PP and SPL.
- 社団法人日本農芸化学会の論文
- 2002-05-23
著者
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YOSHIDA Tadashi
Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University
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KINUGASA Fumitaka
Department of Immunology, Pharmacology Research Labs, Astellas Pharma, Inc.
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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HACHIMURA Satoshi
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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Yoshida Tadashi
Dep. Of Applied Biological Sci. Tokyo Univ. Of Agriculture And Technol.
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Kaminogawa Shuichi
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th
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AMETANI Akio
Applied Biological Chemistry, University of Tokyo
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AMETANI Akio
Department of Applied Biological Chemistry, The University of Tokyo
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Kametani Y
Applied Biological Chemistry University Of Tokyo
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Ametani Akio
Department Of Applied Biological Chemistry The University Of Tokyo:(present Address)torrey Pines Ins
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Habu S
Division Of Host Defense Mechanism Department Of Immunology Tokai University School Of Medicine
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Ishimori Mina
Department Of Applied Biological Chemistry University Of Tokyo
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TOTSUKA Mamoru
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The U
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ISE Wataru
Department of Applied Biological Chemistry, University of Tokyo
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Kaminogawa S
Dep. Of Food Sci. And Technol. Nihon Univ.
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Totsuka Mamoru
Dep. Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Univ. Of
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Totsuka M
Department Of Applied Biological Chemistry The University Of Tokyo
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Totsuka Mamoru
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Hachimura S
Res. Center For Food Safety Graduate School Of Agricultural And Life Sciences The Univ. Of Tokyo
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Ise Wataru
Department Of Applied Biological Chemistry University Of Tokyo
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Yoshida Tadashi
Department Of Applied Biological Science Faculty Of Agriculture Tokyo University Of Agriculture And
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Hachimura Satoshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Kinugasa Fumitaka
Department Of Applied Biological Chemistry University Of Tokyo
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Hachimura Satoshi
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences The Uni
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Yoshida Tadashi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University:(present Office)frontie
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