Prevention of Intestinal Infection by Glycomacropeptide
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概要
- 論文の詳細を見る
The preventive effects of glycomacropeptide (GMP) against intestinal infection were investigated, and conjugates of GMP with xylooligosaccharide (XOS) and carboxymethyldextran (CMD) were prepared by the Maillard reaction to enhance the effect of GMP. The binding ability of GMP to intestinal pathogenic bacteria was evaluated by a binding assay with biotinylated bacteria. GMP showed the ability to bind to Salmonella enteritidis and enterohemorrhagic Escherichia coli O157:H7 (EHEC O157). This binding ability was decreased by a sialidase treatment and completely eliminated by periodate oxidation. These results indicate that such carbohydrate moieties as sialic acid in GMP are involved in binding to S. enteritidis and EHEC O157. The preventive effect of GMP on the adhesion of pathogenic bacteria to Caco-2 cells was also investigated. GMP showed an inhibitory effect on the adhesion of EHEC O157 in a dose-dependent manner, although it was not a potent inhibitor of the adhesion of Salmonella infection. However, in the case of Salmonella infection, GMP–XOS and GMP–CMD significantly suppressed IL-8 production which was the index of infection. Our results indicate GMP to be a promising agent for preventing intestinal infection.
- 社団法人 日本農芸化学会の論文
- 2005-12-23
著者
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Yoshida Tadashi
Dep. Of Applied Biological Sci. Tokyo Univ. Of Agriculture And Technol.
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Sugita Konishi
Division Of Microbiology National Institute Of Health Sciences
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Sugita Konishi
Division Of Microbiology The National Institute Of Health Sciences
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YOSHIDA Tadashi
Institute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo Univers
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HATTORI Makoto
Institute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo Univers
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Hattori Makoto
Dep. Of Applied Biological Sci. Tokyo Univ. Of Agriculture And Technol.
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Hara Kudo
Division Of Microbiology National Institute Of Health Sciences
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Hara Kudo
Division Of Microbiology The National Institute Of Health Sciences
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Hara Kudo
Division Of Microbiology National Institute Of Health Science
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KOBAYASHI HATTORI
Division of Microbiology, National Institute of Health Sciences
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NAKAJIMA Kouhei
Institute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo Univers
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TAMURA Norimitsu
Institute of Symbiotic Science and Technology, Division of Agriscience and Bioscience, Tokyo Univers
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IKEDO Masanari
Eiken Chemical Co., Ltd.
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Ikedo Masanari
Eiken Chemical Co. Ltd.
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Nakajima Kouhei
Institute Of Symbiotic Science And Technology Division Of Agriscience And Bioscience Tokyo Universit
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Tamura Norimitsu
Division Of Agriscience And Bioscience Institute Of Symbiotic Science And Technology Tokyo Universit
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Kobayashi Hattori
Division Of Microbiology The National Institute Of Health Sciences
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Kobayashi Hattori
Division Of Microbiology National Institute Of Health Sciences
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Yoshida Tadashi
Institute Of Applied Microbiology Faculty Of Agriculture Hokkaido University
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Kobayashi-Hattori Kazuo
Division of Microbiology, National Institute of Health Sciences
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Hattori Makoto
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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