Distinctly Different Sensitivity in the Induction and Reversal of Anergy of Th1 and Th2 Cells
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概要
- 論文の詳細を見る
T cell anergy is one of the mechanisms of immunological tolerance. We examined in this study the distinct responses of Th1 and Th2 cells to in vitro anergic stimulation using Th1 and Th2 cells from two strains of T cell receptor transgenic mice. Proliferation of the Th2 cells was difficult to suppress by anergic stimulation, while that of Th1 cells was significantly inhibited even by weak stimulation. However, IL-4 production by Th2 cells was definitely reduced by anergic stimulation, although the inhibition level of IL-4 was lower than that of IFN-γ production by Th1 cells. We also examined the reversal of anergy in both subsets. While both the anergized Th1 and Th2 cells responded to IL-2 stimulation, only the anergy of the Th2 cells could be reversed. This result indicates that progression of the cell cycle was not sufficient for anergy reversal in Th1 cells. Our findings indicate that the induction and reversal of T cell anergy might be affected by the distinct signaling features of Th1 and Th2 cells.
- 社団法人 日本農芸化学会の論文
- 2007-01-23
著者
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Hattori Makoto
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
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Yoshida Tadashi
Department Of Applied Biological Science Faculty Of Agriculture Tokyo University Of Agriculture And
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Hattori Makoto
Department Of Agricultural Chemistry The University Of Tokyo
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Yoshida Tadashi
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
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EBIHARA Masato
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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Yoshida Tadashi
Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University:(present Office)frontie
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Ebihara Masato
Department Of Applied Biological Science Tokyo University Of Agriculture And Technology
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Hattori Makoto
Department of Applied Biological Science, Tokyo University of Agriculture and Technology
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