Novel Linkage Disequilibrium of Single Nucleotide Polymorphisms in the Transcriptional Regulatory Region of μ-Opioid Receptor Gene in Japanese Population(Molecular and Cell Biology)

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概要

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• μ-Opioid receptor agonists, such as morphine, are widely applied in pain therapy clinical practice. However, the effects exerted by morphine via receptor are influenced by individual specificity. Single nucleotide polymorphisms (SNPs) in μ-opioid receptor gene (OPRM1) have been reported to influence receptor expression and function. Subsequently, we analyzed SNPs frequency and linkage disequilibrium associated with OPRM1 transcriptional region and 4 exons among healthy Japanese individuals. Consequently, we detected 10 SNPs (-1748G/A, -1565T/C, -1045A/G, -172G/T, -38C/A, 118A/G, ivs2+31 G/A, ivs2+691 C/G, ivs4+274 A/G, and ivs4+435 G/A). Moreover, linkage analysis revealed novel linkage between -1748G/A and -172G/T, which was not observed in studies performed in other nations. In contrast, SNPs frequency detected in this study was similar to previously reported results on Asians; however, linkage disequilibrium reports from different nations differed. These results possibly provide useful information for OPRM1 genotyping in the Japanese population.

• 2009-04-01

著者

• ONO Takeshi

  Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University

• MUTO Akihiro

  Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University

• KANEDA Toshio

  Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University

• ARITA Eri

  Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University

• YOSHIDA Tadashi

  Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University

• Arita Eri

  Department Of Pathophysiology Faculty Of Pharmaceutical Sciences Hoshi University

• Muto Akihiro

  Department Of Pathophysiology Faculty Of Pharmaceutical Sciences Hoshi University

• Kaneda Toshio

  Department Of Pathophysiology Faculty Of Pharmaceutical Sciences Hoshi University

• Kaneda Toshio

  Department Of Cardiovascular Medicine Hanwa Senboku Hospital

• Yoshida Tadashi

  Department Of Applied Biological Science Faculty Of Agriculture Tokyo University Of Agriculture And

• Ono Takeshi

  Department Of Orthopaedics Osaka University Graduate School Of Medicine

• Ono Takeshi

  Department Of Pathophysiology Faculty Of Pharmaceutical Sciences Hoshi University

• Yoshida Tadashi

  Department Of Pathophysiology Faculty Of Pharmaceutical Sciences Hoshi University

• Yoshida Tadashi

  Department Of Agricultural Chemistry Faculty Of Agriculture Kyoto University:(present Office)frontie

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• Novel Linkage Disequilibrium of Single Nucleotide Polymorphisms in the Transcriptional Regulatory Region of μ-Opioid Receptor Gene in Japanese Population(Molecular and Cell Biology)
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