Antigenicity of Modified β-Lactoglobulin Examined by Three Different Assays
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概要
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The effects of chemical modifications on the antigenic properties of bovine β-lactoglobulin was studied by three different assay systems with IgG antibodies; immuno-double diffusion, quantitative immunoprecipitin assay, and radioimmunoassay. Carboxymethylation, succinylation, and guanidination seemed not to disturb the antigenicity of β-lactoglobulin in immuno-double diffusion, but the decrease in the affinity of these derivatives for anti-β-lactoglobulin antibody was observed in the quantitative immunoprecipitin assay and radioimmunoassay. Nitrophenylsulfenylation or reduction and Carboxymethylation seemed to delete one of the antigenic sites of β-lactoglobulin judging from the data of immuno-double diffusion, but the results from the quantitative immunoprecipitin assay and radioimmunoassay showed that reduction and Carboxymethylation affected the antigenicity of β-lactoglobulin more strongly than nitrophenylsulfenylation did.
著者
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Watanabe Soichiro
Department Of Chemistry Graduate School Of Science The University Of Tokyo
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Yamauchi Kunio
Department Of Agricultural Chemistry The University Of Tokyo
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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KURISAKI Junichi
Department of Animal Products, National Institute of Animal Industry
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Nakamura Shuji
Department Of Cardiovascular Medicine Hiroshima University Graduate School Of Biomedical Sciences
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Hattori Makoto
Department Of Agricultural Chemistry The University Of Tokyo
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HATTORI Makoto
Department of Agricultural Chemistry, The University of Tokyo
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HOTTA Keiko
Department of Agricultural Chemistry, The University of Tokyo
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KURISAKI Junichi
Department of Agricultural Chemistry, The University of Tokyo
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WATANABE Soichiro
Department of Agricultural Chemistry, The University of Tokyo
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NAKAMURA Shuji
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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