Comparison of pH and Ionic Strength Dependence of Interactions between Monoclonal Antibodies and Bovineβ-Lactoglobulin
スポンサーリンク
概要
- 論文の詳細を見る
A panel of 13 monoclonal antibodies (mAbs) against distinct determinants on bovine β-lactoglobulin, a model protein antigen, were examined and compared for their ability to bind and desorb from the antigen at differing pHs and ionic strengths by an enzyme-linked immunosorbent assay and elution assay. Among them, mAb 61C1 was found to be highly sensitive to the pH, and 3 in 4 mAbs directed to the region 42-56 also strongly depended on the change in ionic strength. Because of the large proportion of charged amino acid residues in the region 42-56, the electrostatic forces are considered to be more predominant than the hydrophobic interactions in the latter antigen-antibody reactions, thereby resulting in their high sensitivity to the ionic strength.
- 社団法人日本農芸化学会の論文
- 1996-01-23
著者
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NAKAMURA KOZO
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo
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ENOMOTO Atsushi
Department of Pathology, Nagoya University Graduate School of Medicine
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KURISAKI Jun-ichi
National Institute of Agrobiological Sciences
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KAMINOGAWA Shuichi
Department of Food Science and Technology, College of Bioresource Sciences, Nihon University
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ISHIDA Satoshi
Department of Microbiology, Kobe University Graduate School of Medicine
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Kaminogawa Shuichi
Department Of Applied Biological Chemistry Division Of Agriculture And Agricultural Life Sciences Th
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Nakamura Kozo
Department Of Bioscience And Biotechnology Faculty Of Agriculture Shinshu University
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Kaminogawa S
Dep. Of Food Sci. And Technol. Nihon Univ.
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KAMATA Naoshi
Department of Biological and Chemical Engineering, Faculty of Engineering, Gunma University
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Enomoto Atsushi
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Kaminogawa Shuichi
Department Of Agricultural Chemistry Faculty Of Engineering The University Of Tokyo
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Kurisaki J
National Institute Of Agrobiological Sciences
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Ishida Satoshi
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Kamata Naoshi
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Nakamura Kozo
Department Of Agricultural Chemistry The University Of Tokyo
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Nakamura Kozo
Department Of Biological And Chemical Engineering Faculty Of Engineering Gunma University
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Kurisaki Jun-ichi
National Food Research Institute
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