Down-Regulation of mdr1b mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride
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概要
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We investigated the change in renal mdr1b mRNA expression in offspring exposed to tributyltin chloride (TBTC) via the placenta and lactation or via lactation, using the real-time reverse transcription-polymerase chain reaction. Pregnant ICR mice were given water containing TBTC (0, 15, and 50 μg/ml) ad libitum from the start of pregnancy to weaning or from parturition to weaning. Exposure via the placenta and lactation significantly reduced the renal mdr1b level in offspring. Exposure to TBTC through the mother might impair the exclusion system of toxic compounds in offspring.
- 社団法人 日本農芸化学会の論文
- 2006-05-23
著者
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KIMURA Kimiko
Department of pathology, Nippon Medical School
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Sugita Konishi
Division Of Microbiology National Institute Of Health Sciences
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Kimura Kimiko
Department Of Pathology Nippon Medical School
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Kimura Kimiko
Department Of Veterinary Medical Sciences The University Of Tokyo
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KOBAYASHI HATTORI
Division of Microbiology, National Institute of Health Sciences
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WATANABE Takahiro
Division of Food, National Institute of Health Sciences
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Kobayashi Hattori
Division Of Microbiology The National Institute Of Health Sciences
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Kobayashi Hattori
Division Of Microbiology National Institute Of Health Sciences
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Watanabe Takahiro
Division Of Food National Institute Of Health Sciences
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Kobayashi-Hattori Kazuo
Division of Microbiology, National Institute of Health Sciences
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- Down-Regulation of mdr1b mRNA Expression in the Kidneys of Mice Following Maternal Exposure to Tributyltin Chloride
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