Daunomycin Biosynthesis by Microbial Conversion of Precursor Metabolited Using Biosynthetically Blocked Mutants

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概要

• 論文の詳細を見る

• The biosynthetic pathway of daunomycin (DM) from intermediate aglycone alkavinone (AKN) is studied by biosynthetic conversion of various precursors using non-DM-producing blocked mutants. DM formation starts by (i) 11-oxidation of AKN to yield ε-rhodomycinone (ε-RMN) and is then achieved by at least six biosynthetic steps in the following order; (ii) 7-O-daunosaminylation of ε-RMN to yield D788-6 (5A : 7-O-daunosaminyl ε-RMN); (iii) 10-demethylesterification to yield D788-1 (RP : 10-carboxy-13-deoxyocarminomycin); (iv) 10-decarboxylation to yield D788-11 (5B : 13-deoxocarminomycin); (v) 4-O-methylation to yield feudomycin A (13-deoxodaunomycin); (vi) 13-oxidatin to yield 13-dihydrodaunomyxin; (vii) 13-dehydrogenation to yield DM. However, the DM biosynthetic route via carminomycin is not observed. It is also found that most of these possible biosynthetic enzymes involved in DM production can catalyze some related metabolities other than their practical precursors.

• 社団法人日本生物工学会の論文
• 1995-03-25

著者

• YOSHIMOTO Akihiro

  Faculty of Applied Biological Science, Hiroshima University

• JOHDO Osamu

  Central Research Laboratories, Mercian Corporation

• Yoshimoto Akihiro

  Faculty Of Applied Biological Science Hiroshima University

• Nakamura Tomohiko

  Faculty Of Applied Biological Science Hiroshima University

• TONE Hiroshi

  Central Research Laboratories, Mercian Corporation

• Tone Hiroshi

  Central Research Laboratories Mercian Corporation

• KUBO KATSURO

  Central Research Laboratories, Merican Corporation

• Johdo Osamu

  Central Research Laboratories Mercian Corporation

• Kubo Katsuro

  Central Research Laboratories Merican Corporation

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