A Unique Phosphatidylinositol Bearing a Novel Branched-Chain Fatty Acid from Rhodococcus equi Binds to Influenza Virus Hemagglutinin and Inhibits the Infection of Cells.
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概要
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From the aquatic bacterium Rhodococcus equi strain S420, we isolated a substance that strongly binds to influenza viruses. Structural analyses revealed that it is a unique type of phosphatidylinositol (Ptdlns) bearing a branched-chain fatty acid (14-methyloctadecanoic acid). In a TLC/virus-binding immunostaining assay, this Ptdlns bound to all subtypes of hemagglutinin (HA) of influenza A viruses tested, isolated from humans, ducks and swine, and also to human influenza B viruses. Furthermore, the Ptdlns significantly prevented the infection of MDCK cells by influenza viruses, and also inhibited the virusmediated hemagglutination and low pH-induced hemolysis of human erythrocytes, which represents the fusogenic activities of the viral HA. We also used purified hemagglutinin instead of virions to examine the interaction between viral HA and Ptdlns, showing that the Ptdlns binds to hemagglutinin. These findings indicate that the inhibitory mechanism of Ptdlns on the influenza virus infection may be through its binding to viral HA spikes and host cell endosomal/lysosomal membranes, which are mediated by the function of viral HA.
- 社団法人 日本生化学会の論文
著者
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Hidari Kazuya
Department Of Biochemical Cell Research The Tokyo Metropolitan Institute Of Medical Science
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Guo Chao-tan
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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Nakata Kuniho
Central Research Laboratories Mercian Corporation
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Shortridge Kennedy
Department Of Microbiology The University Of Hong Kong University Of Pathology Building Queen Mary H
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Ohta Shinji
Instrument Center For Chemical Analysis Hiroshima University
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Yoshimoto Akihiro
Faculty Of Applied Biological Science Hiroshima University
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Miyamoto Daisei
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences:core Research Fo
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Takahashi Tadanobu
Department Of Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka And Global Coe P
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Suzuki Yasuo
Department Of Applied Physics Faculty Of Engineering Fukui University
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Suzuki Takashi
Department Of Anatomic Pathology Tohoku University School Of Medicine
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Hidari Kazuya
Department of Biochemistry, University of Shizuoka School of Pharmaceultical Sciences
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