Inhibition of Chromosome Separation in Fertilized Starfish Eggs by Kalihinol F, a Topoisomerase I Inhibitor Obtained from a Marine Sponge(Biochemistry & Molecular Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Kalihinol F, a naturally occurring diterpene from a marine sponge, Acanthella sp., inhibited chromosome separation in fertilized starfish (Asterina pectinifera) eggs but allows the first cleavage to occur, thereby forming unseparated metaphase chromosomes which were elongated between the two daughter cells. The chromosomes were eventually torn off in the embryonic cells. Most of the cells gradually lost the chromosomes during the cell cycle progression. The embryonic development halted at the morula stage just before the onset of blastulation. The mitotic failure occurred when kalihinol F was applied to a fertilized egg during the second meiotic process, but not after the completion of the second meiotic division. Kalihinol F inhibited topoisomerase I activity in vitro, but had no effects on activities of DNA polymerases α, β, and γ, and of topoisomerase II. These results suggest that the topoisomerase I plays an essential role in meiosis II in this species.
- 社団法人日本農芸化学会の論文
- 2003-11-23
著者
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OHTA Shinji
Instrument Center for Chemical Analysis, Hiroshima University
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Andoh Toshiwo
Department Of Hygienic Chemistry Meiji College Of Pharmacy
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Andoh Toshiwo
Department Of Bioengineering Faculty Of Engineering Soka University
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Hamaguchi Yukihisa
Department Of Cardiology Nagoya University Graduate School Of Medicine
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Hamaguchi Y.
Fac. Of Applied Biol. Sci. Hiroshima Univ.
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Hamaguchi Y
Department Of Bioengineering Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Tech
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Ohta S
Hiroshima Univ. Higashi-hiroshima Jpn
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Ohta Shinji
Instrument Center For Chemical Analysis Hiroshima University
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Hongo Tomokatsu
Department Of Applied Biochemistry Hiroshima University
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OHTA Emi
Instrument Center for Chemical Analysis, Hiroshima University
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SHIODA Masaki
Department of Biological Science, Faculty of Science, Kumamoto University
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IKEGAMI Susumu
Instrument Center for Chemical Analysis, Hiroshima University
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OHTA Emi
Nagahama Institute of Bio-Science and Technology
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IKEGAMI Susumu
Nagahama Institute of Bio-Science and Technology
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Shioda Masaki
Department Of Biological Science Faculty Of Science Kumamoto University
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Ikegami S
Nagahama Inst. Of Bio-science And Technol.
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Hamaguchi Yukihisa
Department Of Bioengineering Graduate School Of Bioscience And Biotechnology Tokyo Institute Of Tech
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