Improvement of Depression-Like Behavior and Memory Impairment with the Ethanol Extract of Pleurotus eryngii in Ovariectomized Rats
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概要
- 論文の詳細を見る
Ethanol extract of Pleurotus eryngii (DC.) Q<span style="font-variant: small-caps;">UÉL</span> has estrogen-like activities that protect against bone loss caused by estrogen deficiency. In the present study, we investigated the effect of P. eryngii on depression-like behavior and memory impairment in ovariectomized (OVX) rats. Immobility time during a forced swimming test was significantly longer for OVX rats than for sham-operated rats. The depression-like behavior in OVX rats was improved by long-term administration of the ethanol extract of P. eryngii (500 mg/kg body weight (b.w.)/d). Spatial memory impairment in OVX rats assessed by the Morris water maze test was also improved by P. eryngii extract without any effect on motility. These results suggested that P. eryngii extract has estrogen-like improvement activity against depression-like behavior and memory impairment in OVX rats. Additionally, increase in the amount of synaptosomal zinc after ovariectomy was inhibited by P. eryngii extract. Since zinc in synaptic vesicles is important for memory function and is linked to the pathophysiology of depression, normalization of zinc signaling would be involved in the beneficial effect of P. eryngii extract on neurological disorders after ovariectomy.
- 公益社団法人 日本薬学会の論文
著者
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Hidari Kazuya
Department Of Biochemical Cell Research The Tokyo Metropolitan Institute Of Medical Science
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Wakatsuki Akihiko
Department Of Gynecology Kochi Medical School
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Saito Masakazu
Department Of Biochemistry And Molecular Biology Saitama University
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Kanazawa Hiroaki
Department Of Anatomy Niigata University School Of Medicine
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Matsushita Hiroshi
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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Suzuki Takashi
Department Of Anatomic Pathology Tohoku University School Of Medicine
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Minami Akira
Department Of Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka And Global Coe Program
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Saito Masakazu
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Horii Yuuki
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Ieno Daisuke
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Matsuda Yukino
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Ohyama Yuriko
Department of Obstetrics and Gynecology, Aichi Medical University, School of Medicine
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Takeda Atsushi
Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Sabaratnam Vikineswary
Institute of Biological Sciences, Faculty of Science, University of Malaya
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