Glucosyl Hesperidin Prevents Influenza A Virus Replication in Vitro by Inhibition of Viral Sialidase
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概要
- 論文の詳細を見る
Hesperidin, a flavonoid obtained from citrus fruits, is known to have multiple biological activities and antimicrobial activities for human viruses; however, hesperidin has very low solubility in water and the target molecule of hesperidin for influenza virus remains unknown. A water-soluble derivative of hesperidin, glucosyl hesperidin (GH), which was synthesized by regioselective transglycosylation with cyclodextrin glucanotransferase, has been reported to have biological activities that are as or stronger than those of hesperidin. To determine the inhibitory effect of GH on influenza A virus (IAV) infection, Madin–Darby canine kidney (MDCK) cells were treated with GH before, at the same time as, and after IAV inoculation. GH treatment before IAV inoculation had no effect on virus replication, whereas, treatment with GH at the same time as or after IAV inoculation induced distinct reduction in IAV replication. Inhibition analysis of GH against two surface glycoprotein spikes of IAV revealed that GH prevents IAV replication by inhibition of viral sialidase activity that is involved in the entry and release stages on IAV infection but not by receptor binding inhibition. GH had no cytotoxic effects on MDCK cells in a dose range of 0—25 mM. Our results provide useful information for the development of novel sialidase inhibitors for influenza prevention.
- 公益社団法人 日本薬学会の論文
著者
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Takahashi Tadanobu
Department Of Biochemistry School Of Pharmaceutical Sciences University Of Shizuoka And Global Coe P
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Suzuki Takashi
Department Of Anesthesia Showa University Northern Yokohama Hospital
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Saha Repon
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Suzuki Takashi
Department Of Anatomic Pathology Tohoku University School Of Medicine
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Suzuki Takashi
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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Takahashi Tadanobu
Department of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka
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