Selective Binding of Tamsulosin to Genetic Variants of Human α_1-Acid Glycoprotein(Miscellaneous)
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概要
- 論文の詳細を見る
We investigated the characteristics of binding of tamsulosin to α_1-acid glycoprotein (AGP) genetic variants. The binding of tamsulosin to each of the human AGP variants was determined by ultrafiltration, and the binding characteristics for each variant were compared using binding parameters and inhibition of the binding by disopyramide and warfarin. The affinities of tamsulosin binding to a F1/S variant mixture and total AGP variants were relatively high (dissociation constants 1.6 μM). On the other hand, the dissociation constant for variant A was 14.9±2.53 μM. The binding of tamsulosin was competitively inhibited by warfarin but not by disopyra mide. Tamsulosin appears to be a suitable compound for studying the characteristics of drug binding to human AGP F1/S variants under clinical conditions.
- 公益社団法人日本薬学会の論文
- 2007-08-01
著者
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Hanada Kazuhiko
Department of Biopharmaceutics, Meiji Pharmaceutical University
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Ogata Hiroyasu
Deparment Of Biopharmaceutice Meiji Pharmaceutical University
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Ogata Hiroyasu
Department Of Biopharmaceutics Meiji Pharmaceutical University
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Hanada Kazuhiko
Department Of Biopharmaceutics Meiji Pharmaceutical University
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Hanada Kazuhiko
Department Of Biopharmaceutics Meiji College Of Pharmacy
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TOCHIKURA Naohiro
Department of Biopharmaceutics, Meiji Pharmaceutical University
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Tochikura Naohiro
Department Of Biopharmaceutics Meiji Pharmaceutical University
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Hanada Kazuhiko
Department of Biopharmaceutics & Clinical Pharmacokinetics, Meiji Pharmaceutical University
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