THE BIOAVAILABILITY OF FLUFENAMIC ACID FROM ALUMINUM FLUFENAMATE TABLET AND FLUFENAMIC ACID CAPSULE, AND THE INFLUENCE OF FOOD AND ALUMINUM HYDROXIDE GEL
スポンサーリンク
概要
- 論文の詳細を見る
The bioavailabilities of flufenamic acid (I) from a commercial aluminum flufenamate (II) tablet and I capsule were estimated by measuring urinary excretion of I and its metabolites fluorometrically. The dissolution rates of I from both dosage forms were also determined. The effects of concomitant intake of food or antacid on the bioavailabilities from the II tablet and the I capsule were investigated. The extent on I bioavailability from the II tablet was less than 30% of that from the I capsule. Dissolution tests suggested that the low bioavailability of I from II tablet resulted from the extremely slow release of I from the II complex. Intake of a standard meal retarded I absorption from I capsule, but did not affect that from the II tablet. Ingestion of dried aluminum hydroxide gel granules had little effect on I bioavailability from the I capsule.
- 社団法人日本薬学会の論文
著者
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Kaniwa Nahoko
National Institute Of Health Sciences
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Kaniwa Nahoko
Division Of Drugs National Institute Of Hygienic Sciences
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EJIMA AKIRA
National Institute of Hygienic Sciences
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Ogata Hiroyasu
Deparment Of Biopharmaceutice Meiji Pharmaceutical University
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Ogata Hiroyasu
国立医薬品食品衛生研究所
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Ogata Hiroyasu
Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.
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Aoyagi Nobuo
National Institute Of Health Sciences
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Ejima Akira
Drugs Division National Institute Of Hygienic Sciences
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OGATA HIROYASU
Division of Drugs, National Institute of Hygienic Sciences
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AOYAGI NOBUO
Division of Drugs, National Institute of Hygienic Sciences
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EJIMA AKIRA
Division of Drugs, National Institute of Hygienic Sciences
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OGATA Hiroyasu
明治薬科大学大学院臨床薬学薬剤学
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Aoyagi N
National Institute Of Health Sciences
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Aoyagi Nobuo
Division Of Drugs National Institute Of Hygienic Sciences
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Ogata Hiroyasu
Department Of Biopharmaceutics Meiji Pharmaceutical University
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