Comparison of Pharmacokinetics of Individual Teicoplanin Components in Patients(Biopharmacy)

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概要

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• Teicoplanin is a glycopeptide antibiotic comprising six closely related major components whose activities against specific microbial species differ. In order to clarify the significance of monitoring these components separately for determining the therapeutic effectiveness of teicoplanin, we measured the total and unbound concentrations of the main teicoplanin components in plasma and the unbound fractions in patients. Teicoplanin components in plasma were determined separately by, high-performance liquid chromatography following a co-ex-tractive clean-up procedure. The concentrations of unbound teicoplanin components were estimated after plasma ultrafiltration. The plasma concentrations of the main components of teicoplanin were strongly correlated with each other. The apparent elimination rate constants of total bound and unbound teicoplanin calculated by population pharmacokinetic parameters were almost same among the components. Furthermore, the mean population unbound clearance corrected by the unbound fraction was almost the same among the components. These results suggest that monitoring the individual components of teicoplanin has no clinical significance based on the pharmacokinetics of teicoplanin.

• 2007-05-01

著者

• Hanada Kazuhiko

  Department of Biopharmaceutics, Meiji Pharmaceutical University

• Ogata Hiroyasu

  Department of Biopharmaceutics, Meiji Pharmaceutical University

• Ogata Hiroyasu

  Deparment Of Biopharmaceutice Meiji Pharmaceutical University

• Ogata Hiroyasu

  Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.

• HANADA Kazuhiko

  明治薬科大学大学院臨床薬学薬剤学

• Ogata Hiroyasu

  Department Of Biopharmaceutics Meiji Pharmaceutical University

• Ogata H

  Meiji Pharmaceutical Univ. Tokyo Jpn

• Masuhara Keiso

  Department Of Pharmacy St' Marianna University School Of Medicine Hospital

• Hanada Kazuhiko

  Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.

• Hanada Kazuhiko

  Department Of Biopharmaceutics Meiji College Of Pharmacy

• Kimura Toshimi

  Department Of Pharmacy Kitasato University Hospital

• Kimura Toshimi

  Department Of Pathology Kitasato University School Of Medicine

• IKARI Shingo

  Department of Biopharmaceutics, Meiji Pharmaceutical University

• KOUKAKI Yukari

  Department of Biopharmaceutics, Meiji Pharmaceutical University

• UTENA Ayako

  Department of Biopharmaceutics, Meiji Pharmaceutical University

• HAMANO Kunitoshi

  Department of Pharmacy. St. Marianna University Hospital

• ARIKI Hiromune

  Department of Pharmacy. St. Marianna University Hospital

• Utena Ayako

  Department Of Biopharmaceutics Meiji Pharmaceutical University

• Ikari Shingo

  Department Of Biopharmaceutics Meiji Pharmaceutical University

• Koukaki Yukari

  Department Of Biopharmaceutics Meiji Pharmaceutical University

• Masuhara Keiso

  Department Of Pharmacy. St. Marianna University Hospital

• Hanada Kazuhiko

  Department of Biopharmaceutics & Clinical Pharmacokinetics, Meiji Pharmaceutical University

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