Immune Response in Hyperprolactinemia Induced by Sulpiride

概要

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Prolactin (PRL) significantly influences cellular and humoral immunity in animals but there is little information on its role in humans. The aim of this study was to investigate effects on immune system due to the pharmacological modification of PRL levels in 5 healthy individuals. The PRL levels were increased 5-fold (p<0.001) by the administration of sulpiride (150 mg per day orally) which causes hyperprolactinemia. Peripheral blood lymphocyte proliferative response to concanavaline-A, CD4 and CD8 subsets, interleukin-2 (IL-2) production, soluble IL-2 receptor expression and serum cortisol were measured at the duration of euprolactinemia and sulpiride-induced hyperprolactinemia. Significant decreases were observed for IL-2 production (p<0.006) and soluble IL-2 receptor expression (p<0.05) under hyperprolactinemia. Con-A stimulated lymphocyte proliferation, CD4 and CD8 subsets were not different. Sulpiride significantly induced hyperproalctinemia and changed the immune system. Our findings suggest that drug-induced hyperprolactinemia plays a critical role in the regulation of the immune response in man.
北里大学の論文
1999-08-31