INHIBITION OF S-WARFARIN METABOLISM BY NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN HUMAN LIVER MICROSOMES IN VITRO
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概要
- 論文の詳細を見る
We studied the inhibition of S-warfarin metabolism by nonsteroidal antiinflammatory drugs (NSAIDs) in human liver microsomes in vitro. After screening for potential inhibitors among ten NSAIDs using human recombinant cytochrome P450,inhibition kinetic parameters were estimated using human liver microsomes. Phenylbutazone and bucolome were suggested to increase the unbound steady-state level of S-warfarin about four- and five-fold, respectively, as estimated from these metabolic parameters.
- 公益社団法人日本薬学会の論文
- 1998-05-15
著者
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Mihara Kiyoshi
Department of Biopharmaceutics, Meiji Pharmaceutical University
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Ogata Hiroyasu
Department of Biopharmaceutics, Meiji Pharmaceutical University
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Ogata Hiroyasu
Deparment Of Biopharmaceutice Meiji Pharmaceutical University
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Mihara Kiyoshi
Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.
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Mihara K
Department Of Biopharmaceutics
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Mihara Kiyoshi
Department Of Biopharmaceutics Meiji Pharmaceutical University
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Ogata Hiroyasu
Department Of Biopharmaceutics
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TAKIGAWA Tomoaki
Department of Biopharmaceutics
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TAINAKA Hitoshi
Central Laboratory Amersham K.K.,
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Tainaka H
Central Laboratory Amersham K.k.
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Tainaka Hitoshi
Central Laboratory Amersham K.k.
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