THE BIOAVAILABILITIES OF ASPIRIN FROM AN ASPIRIN ALUMINUM AND AN ASPIRIN TABLETS AND THE EFFECTS OF FOOD AND ALUMINUM HYDROXIDE GEL
スポンサーリンク
概要
- 論文の詳細を見る
The bioavailability of aspirin from an aspirin aluminum tablet was compared with that from an aspirin tablet in humans by determining total salicylate excreted in the urine. The effects of concomitant intakes of antacid or food on the bioavailability of aspirin were also investigated. The bioavailability of aspirin from an aspirin aluminum tablet was nearly 60% of that from an aspirin tablet. The low bioavailability of aspirin from an aspirin aluminum tablet was caused by slow release of aspirin from the aluminum complex, and not increased by concomitant intake of food. Intake of food, however, reduced both rate and extent of bioavailability of aspirin from an aspirin tablet, but dried aluminum hydroxide gel granules had no effect on the bioavailability of it.
- 社団法人日本薬学会の論文
著者
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Kaniwa Nahoko
National Institute Of Health Sciences
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Kaniwa Nahoko
Division Of Drugs National Institute Of Hygienic Sciences
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EJIMA AKIRA
National Institute of Hygienic Sciences
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Ogata Hiroyasu
Deparment Of Biopharmaceutice Meiji Pharmaceutical University
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Ogata Hiroyasu
国立医薬品食品衛生研究所
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Ogata Hiroyasu
Dep. Of Biopharmaceutics Meiji Pharmaceutical Univ.
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Aoyagi Nobuo
National Institute Of Health Sciences
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Ejima Akira
Drugs Division National Institute Of Hygienic Sciences
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OGATA HIROYASU
Division of Drugs, National Institute of Hygienic Sciences
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AOYAGI NOBUO
Division of Drugs, National Institute of Hygienic Sciences
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EJIMA AKIRA
Division of Drugs, National Institute of Hygienic Sciences
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OGATA Hiroyasu
明治薬科大学大学院臨床薬学薬剤学
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Aoyagi N
National Institute Of Health Sciences
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Aoyagi Nobuo
Division Of Drugs National Institute Of Hygienic Sciences
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Ogata Hiroyasu
Department Of Biopharmaceutics Meiji Pharmaceutical University
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