Effects of Atropine and Loperamide on the Agitating Force and GI Transit Time in Dogs in Drug Absorption Studies
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概要
- 論文の詳細を見る
There are difficulties in drug absorption studies using dogs because of different gastrointestinal (GI) conditions between these animals and humans, including shorter intestinal transit time and strong agitation force in the GI tract. We attempted to modify the agitation force and GI transit time using atropine and loperamide. The agitation force was examined based on in vitro/in vivo correlation for two controlled release (CR) formulations of acetaminophen. Atropine treatment considerably reduced the agitating force whereas that of loperamide did not.
- 公益社団法人日本薬学会の論文
- 1996-10-15
著者
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Nishio Kazuto
Shien-laboratory National Cancer Center Hospital
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Aoyagi Nobuo
National Institute Of Health Sciences
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Aoyagi Nobuo
国立医薬品食品衛生研究所
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Aoyagi N
National Institute Of Health Sciences
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Kojima Shigeo
National Institute Of Health Sciences
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KATORI Noriko
National Institute of Health Sciences
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Kojima S
National Institute Of Health Sciences
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Katori N
National Cancer Center
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