Molecular Mobility of Lyophilized Poly(vinylpyrrolidone) and Methylcellulose as Determined by the Laboratory and Rotating Frame Spin-Lattice Relaxation Times of ^1H and ^<13>C

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Laboratory- and rotating- frame spin-lattice relaxation times (T_1 and T_<1p>) of ^1H and ^<13>C in lyophilized poly(vinylpyrrolidone) (PVP) and methylcellulose (MC) are determined to examine feasibility of using T_1 and T_<1p> as a measure of molecular motions on large time scales related to the storage stability of lyophilized formulations. The T_<1p> of proton and carbon was found to reflect the mobility of PVP and MC backbones, indicating that it is useful as a measure of large-time-scale molecular motions. In contrast to the T_<1p>, the T_1 of proton measured in the same temperature range reflected the mobility of PVP and MC side chains. The Tl of proton may be useful as a measure of local molecular motions on a smaller-time-scale, although the measurement is interfered by moisture under some conditions. The temperature dependence of T_1 and T_<1p> indicated that methylene in the MC molecule had much higher mobility than that in the dextran molecule, also indicated that methylene in the PVP side chain had a higher mobility than that in the MC side chain.
公益社団法人日本薬学会の論文
2003-11-01